Port Lincoln is a regional community where touch is surviving in the Australian rules dominated state of South Australia. Being 600km from their governing body (Touch SA) and with very little access to develop a higher level of playing standard, Port Lincoln is a real touch outpost. Touch was introduced to Port Lincoln nearly 20 years ago through the local high school, before disappearing for several years. Club contact Gavin Walding credits the touch revival in Port Lincoln to Peter Tokarski in the early 1990’s. With a regional population of 15,000 and the enormous variety of sports, touch is considered one of the area’s strong fringe sports. Participation has varied from 200-400 over the past few years, with a good number of those players being juniors. The winter season is a small competition, with just a few sides. One side consists of over 45’s while another is based around seven junior players. All of the competitions are mixed with participation of numbers being the goal. It is for this reason they allow seven players on the field per side. During summer a junior after-school competition is run with great support from Touch SA, local schools and teachers. While you may be reading this and thinking Port Lincoln sounds like many other normal regional touch associations, it’s time to think again. This is their ANZAC Day clash or Easter matches of the AFL or NRL…It’s called the Cummins Classic and it’s certainly becoming classic. This year July 29th is the date. Both sides will embark on a tense combined 140km bus trip to Cummins, to play up bush in a regular grudge match between two sworn enemies. For six or seven local Cummins players, this is the one match played on their home turf and local pride is also at stake. Gavin Walding believes the Cummins Classic, about to enter it’s second year under the official title, but having been played for over five years now, could well become a Port Lincoln touch institution. “The Cummins classic is a great night with some of the 300 odd locals wandering down to watch the mad buggers that throw the ball backwards to go forwards,” he says. “It is also a great opportunity for the genuine footy bus trip with many a foggy head in the morning.” The teams taking the field for this year’s Cummins Classic are The Masters and The Rik Rik’s. Peter Tokarski (the legend credited with Port Lincoln’s touch revival) leads the Masters, who are the usual collection of those continuing to defy both physics and age to take the field, with their oldest player being over 60. The Masters make up a large proportion of the SA 45’s & 50’s masters sides, who have competed since the 1999 Australian masters with various success. Their opponents for the past two years have been a group of players based around the United Yeelanna football club, whose home ground is around 90km from Port Lincoln. Many of the Rik Rik’s are ex-students of the Masters’ leader, Peter Tokarski. For this auspicious round a few ring-ins tend to appear, along with around 300 locals, who may not fully understand the rules, but love the intensity and the underlying fun of the game. “By the end of the Classic the locals are yelling & cheering along with the players, helped of course by the bar conveniently located next to the field,” Gavin Walding says. After the game the best player receives their medallion and the winners gloat in their short-lived glory. Players and spectators alike then adjourn to the pub across the road for a chance to catch up with friends before boarding the bus for the trip back home. Keep tuned for a full match report in following months. By Rachel Moyle
Ex-Real Madrid GM Mijatovic: Zidane doesn’t know what to doby Carlos Volcanoa month agoSend to a friendShare the loveFormer Real Madrid GM Pedja Mijatovic has questioned whether Zinedine Zidane is capable of leading the club out of it’s slump.Mijatovic was reacting to their 3-0 Champions League humbling at PSG.He said, “I did not expect such a game. I expected to see another game, I was very confident and I hope that Madrid will present itself in a better way in a competition in which it has made history. “PSG has been better in every way. It is a worry. The season looks like last year.”From minute one, Madrid was not involved in the game. When a team lets you play they all seem like phenomena to you. Madrid has to improve a lot. They have to worry and look for solutions. I don’t see Zidane finding solutions or helping the team to improve.” About the authorCarlos VolcanoShare the loveHave your say
14May Rep. Markkanen announces Outstanding Educator Award recipients Categories: Markkanen News State Rep. Greg Markkanen announced today the 2018-2019 Outstanding Educator Award recipients.The award winners are Luke Theisen of Horizons Alternative High School, Laura Augustine of L’Anse Area Schools, and Heather French of Lake Linden-Hubbell Schools.Luke Theisen has been vital in the creation of Horizon’s “Student First Initiative,” a program that aims to strengthen the student body by decreasing stressful factors, promoting attendance and reducing discipline referrals. Theisen has taught English for the past 10 years.Heather French has gone above and beyond the call of a typical teacher. French has been known to help with assisting students with tough life events, helping out with scholarship applications, and even helping prepare students for prom. She teaches English in grades 7-9.Laura Augustine has been involved in the L’Anse community in multiple ways. Augustine has organized the annual Variety of Music Show, led students on numerous trips oversees, and organized the L’Anse Literacy Club. She has also been the choir director at L’Anse United Methodist Church for over 25 years. Augustine has received awards including Outstanding Education Employee from the Copper Country Association of School Boards and the Distinguished Educator Award. She has taught English and study skills for over 20 years.
Fátima BarrosPortuguese regulator ANACOM’s president Fátima Barros has taken over the presidency of BEREC, the international telecom regulators association that brings together 28 European regulators. Barros will be charged with leading BEREC’s ongoing work on the European Connected Continent proposals developed by former EC vice-president Neelie Kroes last year, including regulations covering international roaming tariffs, net neutrality and spectrum use.
UK broadcaster Channel 4 has chosen Yospace to provide technology for targeted video advertising across its online content.Channel 4 previously announced that it was moving away from traditional linear ad feeds across its digital properties to dynamically served, targeted ads. The broadcaster will replace its pre-scheduled blocks of inventory with targeted live video advertising, which will be available to buy programmatically by the end of the year.Yospace is provideing in-stream ad replacement with transitions to and from the advertising. Insertions are performed server-side and veiwers are presented with ads that are customised according to their unique user profile, according to Yospace.The recent agreement with Yospace is part of the second phase of the All 4 launch – the broadcaster’s new online destination. All 4 initially introduced ad insertion for VOD, and will now use the Yospace solution to launch personalised ad insertion into the live stream.Yospace says that the latest data show that deployments of its technology has brought view-through rates for dynamic advertisement replacement up to 98.7% for broadcasters.“For Channel 4’s registered viewers, the All 4 experience is becoming even more personalised. We have leading audience insight capabilities and a database of more than 12 million viewers who can access a bespoke set of content and related experiences. This ethos is increasingly carried throughout our advertising, and the Yospace solution will enable us to deliver personalised ads to both individuals and specific groups seamlessly into the live stream,” said Jonathan Lewis, Head of Digital Innovation and Partnerships.“Our programmatic launch has also opened up a host of opportunities around what we do with our live feed generally – and we’re currently exploring what place dynamic ad serving could have on the big screen.”Yospace CEO, Tim Sewell said: “Our technology is already driving substantial advertising views for a growing number of broadcasters, and is ideally suited to Channel 4’s requirements. We are delighted to be working with such an esteemed broadcaster who already leads the field in providing the most personalised viewer experience. Our solution will enable it to leverage its extensive user database to really maximise revenues through personalised and seamless live ad insertion. A solution like this will only work if it’s reliable and stable enough to cope with major TV audiences, as potentially millions of viewers will tune in at the same time. Another fundamental requirement is flexibility. Timings of the ad breaks in live programming are often fluid, so ad replacements have to be applied on-the-fly, in real-time, and with scale.”
Entrepreneur Store Add to Queue –shares April 1, 2019 Disclosure: Our goal is to feature products and services that we think you’ll find interesting and useful. If you purchase them, Entrepreneur may get a small share of the revenue from the sale from our commerce partners. Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Contributor The ‘Master Microsoft Excel Macros and Excel VBA’ class shows you how to automate and customize tasks for faster reports and more intuitive spreadsheets. Next Article This Excel Course Can Help You Climb the Career Ladder Enroll Now for $5 Image credit: LinkedIn Sales Navigator Data Management Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Time management is a popular topic for entrepreneurs. Everyone wants to know how to crack the code that will help them work more efficiently without sacrificing quality, and how to finish their workday with enough time left to kick back and relax with friends or family.Managing your time well is especially difficult when you’re starting out in a new job. Juggling meetings, keeping track of your team members, and learning entirely new systems and processes are all stress-inducing.However, if you’re smart and selective about which tools you choose to invest your time in, you can save yourself a lot of time on your other tasks. Ninja-level knowledge of essential programs like Excel can help you automate tasks and take a load off of your plate. The Master Microsoft Excel Macros and Excel VBA Course teaches you how to master Excel’s automation and programming functions for smarter spreadsheets and individualized tasks.Excel Macros are actions or sets of actions that you can run repeatedly. They’re great for automating tasks that you perform on a regular basis, like monthly accounting reports or weekly inventory counts. Excel Visual Basic for Applications, or VBA, lets you create and define functions within Excel. It’s an extension on Macro programming that allows for greater automation and customization.Both of these tools can save you tons of time and headaches, and you can learn how to master them with this three and a half hour class. Hands-on projects take you through Excel basics, like formatting and title placement, then you’ll learn how to interact with other users of your Macros through input and message boxes.You’ll clean up multiple Excel worksheets and prep the data that you need to report, then use Macros and VBA to create that report based on data sets that are spread across multiple sheets. When you’re all done, you’ll know how to save time with Excel and you’ll have a Certificate of Completion to back it up.The Master Microsoft Excel Macros and Excel VBA course usually costs $50, but right now you can boost your time management through automated tasks for just $15 (70 percent off). 2 min read
Regulators Keep Punishing Square for Doing Nothing Wrong Technology 2019 Entrepreneur 360 List –shares Do U.S. citizens really need to be protected from Square?The mobile-payment processor has lost another regulatory fight, this time in Florida, where it agreed to pay a $507,000 fine to settle charges it operated in that state without a money-transmission license.Square has been the subject of such spats before, in its home state of California and Illinois, where it actually faced a high-profile cease-and-desist order before getting a license.There remains a valid legal question to these licensure fights: Since Square simply processes payment information, and doesn’t actually transmit money itself, why should it have to fall under the transmission regulations of all 50 states?Related: U.S. Regulators Aim to Close ‘Wild West’ Frontier of BitcoinPresumably, Square has made a decision that, rather than fight each jurisdiction, it will just bend a knee before the regulators, pay whatever fees it needs to in order to fall under their framework, and happily go about its business. Indeed, it has big plans, and there is a good business reason for the company to not stand its ground and fight back.Still, the controversy over Square regulation remains troubling for those outside the company, particularly those entrepreneurs with financial businesses who want to operate across the nation.For one thing, Square’s acquiescence leaves the legal issues unresolved. Square was not a money transmitter by any definition. True, its business changed somewhat when it unveiled plans to get into the gift-card business, but the Florida action doesn’t address that move. The fine Square is paying covers a period of time from February 2010 to November 2012 when it was simply processing transactions.Square could have avoided the fine by fighting its case. That could have led to a precedent that it could use in navigating the Byzantine regulatory frameworks financial-services companies face wherever they do business. Instead, it coughed up $507,000 – small beer to a company that has raised well north of $300 million – and left the fight to others. (To be fair, Square isn’t alone. In its infancy, PayPal decided such a battle wasn’t worth its trouble either.)In addition to not settling the law, Square’s surrender doesn’t allow us to address a key point of the regulations themselves: What ill befell the citizens of Florida from 2010 to 2012 because Square operated without a license? Proponents of regulations like to point out that government’s role is to protect citizens from harm, particularly from greedy businessmen who pick pockets and poison kittens on their way to the top. Government’s noble role is necessary to keep free enterprise from giving in to its baser nature when the sun goes down.Related: Why the EPA and FAA Are Killing Elon Musk’s Better IdeaBut no one can say that Square did anything wrong – or was even in a position to – in Florida or any other state. It processed transactions for merchants and took a cut off the top. It didn’t hold a single dollar, ruble, Deutsche mark or Bitcoin along the way. Merchants could have screwed their customers, and banks could have screwed their merchants, but Square was chaste.Still, asking if someone is actually harmed is no longer a litmus test for the promulgation of regulations. In this case, existing laws never anticipated a company like Square in the first place – a testament to Jack Dorsey’s innovation. Faced with something they had never seen before, regulators decided to pound this Square peg into Florida’s round holes and declare victory.It could have been worse – and may still be. One could argue this is the best-case scenario, since lawmakers always have the option of creating new laws which lead to the promulgation of new regulations that are often worse than the ones before. Rarely is there true reform when it comes to laws and regulations. Rather, there is addition. Only in the legislative world does one ease a burden by adding more weight.Square, for its part, no doubt made the right move for business reasons. But one can’t help but despair of the missed opportunity to make regulators stop bullying entrepreneurs whose innovations are light-years ahead of our regulatory framework. Until some company or business owner draws a line in that sand, businesses will be at more risk of harm than the consumers our lawmakers and bureaucrats seem so eager to protect.Related: Why California Can’t Be Home to the Hyperloop Editor-at-Large Ray Hennessey August 16, 2013 Opinions expressed by Entrepreneur contributors are their own. Image credit: Digital Trends Add to Queue Guest Writer The only list that measures privately-held company performance across multiple dimensions—not just revenue. Next Article 4 min read Apply Now »
China has earned a reputation as the hacker capital of the world, but a new report shows the bulk of global cyber-attack activity has recently come from its smaller neighbor Indonesia.Thirty-eight percent of cyber attacks originated in Indonesia during the second quarter of 2013, up from 21 percent in the first quarter, according to a report by security cloud platform Akamai. This spike helped push China off the hacking pedestal, with the world’s most populous country accounting for 33 percent of attacks, down from 34 percent in the previous quarter. The U.S. rounded out the top three, generating 6.9 percent of cyber-attack traffic, a decrease from 8.3 percent.Indonesia and China alone accounted for more than half of all cyber-attack activity during the quarter.Related: Don’t Get Hacked — Tools to Fight Cyber AttacksWhile it may seem like Indonesia came out of nowhere to take the lead (last year the country accounted for on average less than one percent of cyber crimes), hackers may be taking advantage of its increase in connection and weakening IT structure. The country’s average internet connection speed increased 125 percent in the second quarter from the same time last year. That, coupled with the fact the country isn’t spending a whole lot of cash on its infrastructure, may make the country a haven for cybercriminals.Related: Cyber Security a Growing Issue for Small Business In January, hacker group Anonymous Indonesia claimed responsibility for defacing 12 government websites with the tagline “No Army Can Stop an Idea” shown on the sites. In April, the country’s defense minister Purnomo Yusgiantoro announced they were building a Cyber Defense Center to take on hackers. Microsoft also felt the supposed wrath of Indonesia criminals (among others) when it put the kibosh on a cybercrime operation in June. Akamai’s findings are based on agents reporting log connection attempts, which the company defines as attack traffic. The company then can determine the top countries the hack attacks occur. One caveat to keep in mind: the IP address assigned to a particular country may not be the nation the attacker resides. So someone from China with an IP address associated with them, may be committing cyber attacks in France.To check out more of Akamai’s findings, check out the below highlights:Click to Enlarge+ October 16, 2013 Special Projects Director and Founder of This Dog’s Life Think China is the No. 1 Country for Hacking? Think Again. Next Article Andrea Huspeni Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now » Technology Entrepreneur Staff 2 min read Free Webinar | July 31: Secrets to Running a Successful Family Business –shares Add to Queue
Hewlett-Packard Hewlett-Packard Enterprise agreed to sell its software business to Micro Focus in a $8.8 billion deal that shrinks the Silicon Valley pioneer again while catapulting the little-known British firm into the top tier of European tech companies.Autonomy, the British firm bought by HP in an ill-fated $11 billion push into software just five years ago, will return to British control after the deal for far below its original price.HPE Chief Executive Meg Whitman is focusing the group on a few areas such as networking, storage and technology services since it separated last year from computer and printer maker HP Inc.”Micro Focus’s approach to managing both growing and mature software assets will ensure higher levels of investment in growth areas, like big data analytics and security, while maintaining a stable platform for … software products that customers rely on,” she said.Micro Focus approached HPE in February, four months before Britain voted to leave the European Union in a shock referendum that initially spooked global financial markets, the British firm’s executive chairman, Kevin Loosemore, said.It is the second big deal involving a British company since the June 23 Brexit vote that many feared would put the brakes on mergers. It is also a relatively rare example of a British company buying U.S. technology assets.Loosemore spotted another opportunity to profit from managing old software. Companies including banks and airlines pay Micro Focus to extend the life of the computers they use to run their businesses, for example to manage data. This allows the companies to avoid spending on newer computer systems.”(It) is entirely consistent with our established acquisition strategy and our focus on efficient management of mature infrastructure products,” he told reporters on a conference call from New York.Boring but profitableShares in Micro Focus, based in Newbury, southern England, jumped by a fifth to an all-time high of 2,400 pence, topping the FTSE 100 index of leading shares that it joined days ago, after chip designer ARM Holdings was bought by Japan’s Softbank Corp.Micro Focus, with a market capitalization of 4.45 billion pounds ($6 billion) before the deal, has been snapping up software companies. This would be its largest deal to date. Earlier this year, it acquired U.S. firm Serena Software for $540 million.Loosemore said he would bring the core earnings margin for the mature assets in the deal — about 80 percent of the total — from 21 percent today to Micro Focus’s existing 46 percent level within three years.”The way we do it is really just lots of 101, boring management,” he said. “Too often people chase unattainable growth rates and in doing so they waste a lot of money.”A serial acquirer of software platforms, Micro Focus has also shifted strategy to buying higher growth software such as SUSE, the world’s No.2 maker of Linux software while wringing the most out of aging software.”This strategy works well for current shareholders, who gain significant ownership in better-run businesses,” said UBS analyst Steve Milunovich, who tracks HP Enterprise.The deal, announced along with HPE’s latest quarterly earnings, came on the same day that Dell and EMC Corp completed their merger in a deal that unites two of HPE’s biggest rivals.In the third quarter, HPE reported net revenue of $12.2 billion, down 6 percent from $13.1 billion a year earlier. The transaction is expected to be tax free to HP.The deal is the latest in a series of asset disposals by HPE, which agreed in May to spin off and merge its struggling technology services business to Computer Sciences Corp., in a transaction valued around $8.5 billion.The sale will mean two-thirds of HPE’s remaining business will be hardware, which is fast becoming a commodity, UBS’s Milunovich said. It could make the company a more agile competitor but also could make it harder to compete with far larger companies such as Cisco and Dell.Micro Focus will pay $2.5 billion in cash to HPE, while HPE shareholders will own 50.1 percent of the combined company that will operate under the name Micro Focus and be run by its executives. HPE said it would pay $700 million in one-time costs related to the separation of the assets.Autonomy back in BritainIn the deal, HPE is sending one of the British firms it acquired back to where it started.HPE acquired part of its software portfolio through HP’s $11 billion purchase of Autonomy in 2011, a deal that was supposed to form the central part of the U.S. group’s move into software. HP later wrote off three-quarters of the company’s value.”Some of those [Autonomy] products are very exciting, some of them are more mature,” Loosemore said.Other HPE assets that will be merged include software for application delivery management, big data, enterprise security, information management & governance and IT Operations management businesses.By acquiring the HP Enterprise software assets, the deal thrusts Micro Focus into the top ranks of European software makers. It would rank around sixth in market capitalization terms among regional software names.Since sterling tumbled on the Brexit result, many British companies have become more attractive for international suitors.Loosemore said, however, the Brexit vote didn’t change the dynamic. “If you map our share price in dollars rather than pounds it’s pretty consistent,” he said. “So no real effect.”(By Paul Sandle and Liana B. Baker; Additional reporting by Eric Auchard; Editing by Kate Holton, Guy Faulconbridge, Anna Willard) Free Webinar | July 31: Secrets to Running a Successful Family Business Add to Queue –shares Image credit: Eugene Berman | Shutterstock.com 5 min read Reuters HP Enterprise Strikes $8.8 Billion Deal With Micro Focus for Software Assets September 8, 2016 Chief Executive Meg Whitman is focusing the group on a few areas such as networking, storage and technology services since it separated last year from computer and printer maker HP Inc. 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FacebookMarketing Technology NewsNewsNick ShackelfordStructured Social Previous ArticleNimble Now Selling Its Simple CRM for Office 365 Globally Through Microsoft’s New Commercial MarketplaceNext ArticleRetail App Use Surges 50% As Consumers Shop Year-Round, Taking Pressure Off the “Make or Break’ Holiday Season Structured Social is proud to announce it has been named one of the first recipients of the Preferred Agency Partners Badge under social media giant Facebook’s newly revamped partner program.The Facebook Preferred Marketing Developer program, or PMD, was created to help a business scale its marketing efforts on the Facebook platform. It involves a community of more than 45 countries designed to help marketers and advertisers establish and grow lasting connections with customers. The partnership affords Structured Social access to one-on-one support, advanced tools, training and support, and exclusive opportunities.Marketing Technology News: Introducing Shutterstock Elements, Thousands of Cinema-Grade Video Effects for Filmmakers“Clients know the e-commerce world is more competitive than it has ever been, and they are looking to work with companies that have a real edge,” said Structured Social Co-Founder Nick Shackelford. “This new partnership gives us the type of advantage that will allow us to develop new opportunities for our partners and increase revenue in a substantial way.”Marketing Technology News: GCOM Software Announces Ernie Connon as New Chief Growth OfficerStructured Social has been one of the leading e-commerce companies helping consumer-focused companies drive revenue growth by providing expert consulting on offer structure, page design, paid social campaigns and partnerships with brands. The recognition from Facebook serves as recognition for the company’s efforts, proof that Structured Social is on the right path and clearly demonstrates the company’s position in the marketplace.Marketing Technology News: Blackstone Announces Agreement to Acquire Vungle, a Leading Mobile Performance Marketing Platform Structured Social Named Facebook Preferred Agency Partner MTS Staff Writer6 days agoJuly 17, 2019
Source: https://global.oup.com/ Reviewed by James Ives, M.Psych. (Editor)Oct 11 2018JBI is a peer-reviewed publication that aims to provide high quality, evidence-based content for the global breast imaging medical community. The journal seeks to advance the field of breast imaging, with particular focus on improving patient care and outcomes. JBI will publish original research, as well as reviews of important scientific, educational, and clinical topics.”It’s an honor to oversee the launch of JBI,” says Jennifer A. Harvey, MD, FACR, FSBI, JBI’s Editor-in-Chief. “The journal will provide a focused platform to disseminate scholarly work, as well as practical articles on breast cancer screening, clinical practice aspects of breast imaging, and educational opportunities, with the goal of advancing the global field of breast imaging for the betterment of patient care.”Related StoriesSuper-Resolution Raman Imaging with Plasmonic SubstratesInnovative magnetic nanoparticles show potential for PET/MRI bimodal imaging applicationsAn injection of nanoparticles for spinal cord injuriesSBI’s mission since its inception in 1985 has been to save lives and minimize the impact of breast cancer. JBI is uniquely positioned to advance this mission, according to Jay A. Baker, MD, FACR, FSBI, the Society’s President: “Despite the importance of breast imaging in the lives of countless women – and more than a few men – physicians and scientists seeking new information about the science and clinical practice of breast imaging have had to rely on the relatively few studies found in general interest journals. As the official journal of the Society of Breast Imaging, JBI solves this problem by providing a home for the latest research and clinical guidance for those who practice and those who study all facets of breast imaging.”Alison Denby, publishing director for Oxford Journals, said, “We’re looking forward to working with SBI to launch this much needed outlet for research in breast imaging. SBI is an engaged, dedicated group and we are committed to working together for this journal’s success.”
Analyzing data from a large research program investigating adolescent brain development and mental health, Catherine Orr and colleagues identified brain regions rich in cannabinoid receptors that underwent structural changes in teenagers who reported limited cannabis use. These differences persisted despite controlling for many variables, including sex and socioeconomic status as well as alcohol and nicotine use, and were only apparent after cannabis use. Finally, the researchers demonstrate associations between increased grey matter volume in low-level cannabis users and assessments of reasoning and anxiety.Given the important role of the endogenous cannabinoid system in brain development during adolescence, teenagers may be particularly vulnerable to the effects of THC, the primary psychoactive component of marijuana. Additional research is needed to determine whether these findings apply to more diverse populations beyond the four European countries studied here.Source: http://www.sfn.org/ Jan 16 2019Teenagers who report using recreational marijuana just once or twice display increased volume of numerous brain regions, according to a study of 14-year-olds from Ireland, England, France, and Germany. The research, published in JNeurosci, warrants further study of low-level cannabis use among adolescents amid changing societal attitudes toward the drug.
Source:https://www.uchicagomedicine.org/ Reviewed by Alina Shrourou, B.Sc. (Editor)May 7 2019Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has been gaining ground. A new study from researchers at the University of Chicago finds that women with breast cancer, the most common cancer among women, are at even higher risk from obesity.Breast cancers occur in adipose tissue, better known as fat. Triple-negative breast cancer (TNBC) is a type of breast cancer that is particularly difficult to treat. None of the three most appealing drug targets — the estrogen receptor, the progesterone receptor and human epidermal growth factor receptor 2 — are present on TNBC cells.”These cancers can be particularly aggressive,” said study author Lev Becker, PhD, an assistant professor in the Ben May Department for Cancer Research at the University of Chicago. “For patients with TNBC, there are few therapeutic options. The survival rate is quite low. And the cancer tends to be dramatically elevated in patients who are overweight or obese.”Obesity has become “a global epidemic,” Becker said. The prevalence in the United States is about 36 percent for ages 20 to 39, 43 percent for ages 40 to 59, and 41 percent for those 60 and older. The United States is ranked 12th worldwide for obesity.”Current treatment of breast cancer patients ignores the ongoing obesity epidemic,” said study co-author Marsha Rosner, PhD, the Charles B. Huggins Professor in the Ben May Department for Cancer Research. “In order to take this into consideration, we need to help patients lose weight or identify new drug targets that would be effective in obese cancer patients.”Unfortunately, once the cancer has been detected there may not be time to lose weight prior to treatment. “So our bottom line,” Rosner said, is to “promote weight loss as a cancer prevention measure, incorporate weight loss as a component of therapy for patients with breast cancer, and develop specific drug targets that could be leveraged to address the obesity component of the disease.”Related StoriesStudy reports role of cancer gene in tumor microenvironmentHarnessing target of the brain chemical serotonin to combat obesityBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryIn their paper, “Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer,” published May 3, 2019 in the Journal of Experimental Medicine, Becker, Rosner and colleagues unravel the biology of how obesity promotes TNBC. They show that obesity reprograms macrophages — scavenger white blood cells that can devour invaders such as bacteria, viruses or tumor cells — into pro-inflammatory, metabolically-activated macrophages. Instead of fighting breast cancer, these immune cells actually promote it.”Our studies, in mice and humans,” Becker added, “implicate these metabolically-activated adipose tissue macrophages.” They accumulate in mammary adipose tissue. They release interleukin 6, a pro-inflammatory cytokine which can fuel tumorigenesis. And they thrive on obesity.Interleukin 6 binds to a receptor on the surface of existing cancer cells. That can create “an even more aggressive stem cell phenotype,” Becker said. “These cancer stem cells are able to encourage tumor growth and metastasis, enabling them to travel to other sites.” Patients with advanced or metastatic cancer have higher levels of IL-6 in their blood, which is correlated with poor survival rates.Obesity, the study authors wrote, is a pathological state that “facilitates tumorigenesis by creating tumor permissive conditions in multiple tissues.” This suggests that chronic inflammation and its effects on tumorigenesis may be reversed by targeted anti-inflammatory therapies or by weight loss. Indeed, the researchers found that inducing weight loss in obese mice by feeding them a healthier low-fat diet reversed macrophage inflammation and TNBC tumor formation in mammary fat, even though their body weight remained elevated. These findings highlight the potential value of weight loss, not only as a preventive intervention but even after patients develop breast cancer.
Explore further Amazon’s U.S. digital advertising business is likely to bring in $4.6 billion in 2018, from an estimated $1.8 billion a year ago, eMarketer said.Amazon doesn’t break out sales from advertising, which it reports alongside other lines of business in an “other” category on its financial reports. That segment recorded $2.1 billion in sales during Amazon’s most recent quarter, more than double the year-earlier figure.Amazon has sold ads on its retail websites and on specific product search results for years. But that business began to take off recently with a perception among some ad buyers that Amazon, with its data on what people buy, can help them more precisely determine whether people bought something after seeing advertisements.”People are switching much of their purchasing to online channels, which Amazon is of course driving and benefiting quite heavily from,” said Monica Peart, senior forecasting director of eMarketer. Amazon is also reaping the rewards of an increase in product searches started on the retailer’s website, instead of on Google or another search engine, she said.Google will take in $41 billion in digital ad revenue in the U.S. in 2018, eMarketer estimates, and Facebook $22.8 billion.Amazon was just ahead of rival Microsoft, which, including its LinkedIn professional social networking arm, will post digital ad revenue of $4.5 billion this year, eMarketer estimated. In fifth place is Oath the Verizon-owned grouping of AOL, Yahoo, and other early web stalwarts which will take in $3.6 billion. Amazon.com’s advertising business is likely to more than double its sales in the U.S. this year, a market researcher said Wednesday, which would place the company behind only Google and Facebook. Amazon muscles in on Google’s and Facebook’s advertising turf ©2018 The Seattle Times Distributed by Tribune Content Agency, LLC. Citation: Amazon’s digital ad business surpasses Microsoft, Yahoo, report says (2018, September 24) retrieved 17 July 2019 from https://phys.org/news/2018-09-amazon-digital-ad-business-surpasses.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Image Gallery: 25 Amazing Ancient Beasts Tiny Dino: Reconstructing Microraptor’s Black Feathers About 120 million years ago, a small dinosaur gulped down a lizard, swallowing the reptile whole. The wee lizard’s story might have ended there, but the dinosaur died soon after and was preserved as a fossil. Millions of years later, paleontologists discovered the scaly meal in the dinosaur’s belly. Scientists found the lizard when they examined the fossil of a feathered dinosaur named Microraptor zhaoianus, a small carnivore from the early Cretaceous period (145.5 million to 65.5 million years ago) in what is now northeastern China. In Microraptor’s abdomen was a near-complete skeleton that the researchers identified as a previously unknown lizard species. This “exceptional specimen” paints a clearer picture of the animal diversity in this region during the Cretaceous, and it hints at what was on the menu for dinosaur predators like Microraptor, the scientists reported in a new study. [In Photos: Amber Preserves Cretaceous Lizards]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65935-cretaceous-lizard-in-dinosaur-belly.html?jwsource=cl已复制直播00:0000:3500:35 Microraptor belongs to the theropod (meat-eating) dinosaur group known as the dromaeosaurids — small to medium-size bird-like dinosaurs — which also includes Velociraptor and Deinonychus. It had flight feathers on its front and back limbs, and it could likely glide or even fly, according to the study. The fossilized lizard’s skeleton was still whole and nearly complete, and it appeared to belong to a juvenile. Its position inside the dinosaur’s gut showed that it was gulped down head first, “consistent with feeding behavior in extant carnivorous lizards and birds,” the study authors wrote. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoSoGoodlyThey Were Named The Most Beautiful Twins In The World, Wait Till You See Them TodaySoGoodlyUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoSecurity SaversWindows Users Advised To Do This TodaySecurity SaversUndoBeach Raider24 Photos Of Shelter Dogs The Moment They Realize They’re Being AdoptedBeach RaiderUndoComparisons.org2019: Little-Known Rule in Rowland Heights, CAComparisons.org The new Cretaceous lizard species was found in the abdomen of a Microraptor fossil (indicated by the white rectangle). Credit: Jingmai O’Connor They dubbed the ingested lizard Indrasaurus wangi: The species name honors paleontologist Yuan Wang, director of the Paleozoological Museum of China, and Indrasaurus refers to a legend from ancient Indian texts about the deity Indra, who was swallowed whole by a dragon. Close examination of the lizard’s teeth revealed that they were widely spaced, short-crowned and nearly square. They were unlike the teeth in other Cretaceous lizards, and their unusual shape suggests that the lizard may have had a diet that differed from that of its close relatives, the scientists said in the study. Microraptor and its lizard lunch provide a rare glimpse of direct interactions between predators and prey in ecosystems that vanished millions of years ago. They were found alongside other Microraptor fossils that hold the remains of mammals, fish and birds in their bellies, according to the study. Using these fossils and others from more than two dozen animal groups, the researchers reconstructed a food web showing who ate whom in the Jehol Biota; this site in Liaoning, China — where Microraptor was discovered in 2005 — holds a diverse array of exceptionally preserved fossils dating from 133 million to 120 million years ago. The findings were published online July 11 in the journal Current Biology. Images: Dinosaurs That Learned to Fly