10 months agoLeicester boss Puel to bench Vardy for Man City Cup clash

first_imgAbout the authorChris BeattieShare the loveHave your say Leicester boss Puel to bench Vardy for Man City Cup clashby Chris Beattie10 months agoSend to a friendShare the loveLeicester City boss Claude Puel is set to omit Jamie Vardy from his line-up for their Carabao Cup quarterfinal tie with Mannchester City.Puel is planning to prioritise Saturday’s Premier League match at Chelsea by making a number of changes to his line-up on Tuesday, including starting Vardy on the bench, even though Leicester are three games from Wembley.Vardy, Leicester’s joint-top scorer with five Premier League goals, has been managing a groin problem but returned to fitness for Saturday’s match at Crystal Palace where he played the full 90 minutes against expectations, says the Daily Mail. Puel has been advised Vardy requires some recuperation and has decided to provide it for the visit of City. last_img read more

The Elders Warn Against US Russian Nuclear Strategy Escalation

first_imgThe Elders warned today that new nuclear doctrines and defence rhetoric from the United States and Russia risk a dangerous escalation of tensions that threaten the foundations of global multilateral security infrastructure.

They expressed their concern at the review of nuclear posture recently announced by the United States that raised the prospect of “low-yield” nuclear weapons and a possible nuclear strike in response to a non-nuclear threat.

The Elders also voiced their alarm at the claims in President Vladimir Putin’s state of the union address that Russia has developed a new array of nuclear weapons delivery systems designed to avoid detection.

More fundamentally, The Elders warned that provocative statements from the two sides weakened existing nuclear non-proliferation agreements, and the prospects for their renewal – and that this sends a dangerous signal to other nuclear powers and those with aspirations to secure nuclear weapons for themselves.

Kofi Annan, Chair of The Elders and former United Nations Secretary-General, said:

”The United States and Russia have a particular responsibility as the world’s largest nuclear powers to work together to maintain and strengthen the arms control agreements that have obtained from before the end of the Cold War. Any political or strategic shifts that risk lowering the threshold for nuclear war are dangerously short-sighted, especially in the current climate of geopolitical tension.”

Martti Ahtisaari, Elder, Nobel Peace laureate and former President of Finland, added:

“The optimism many of us felt about the prospects for significant multilateral nuclear disarmament after the end of the Cold War has sadly faded in today’s era of mistrust and rivalry between the two main nuclear superpowers. But the need for responsible action to sustain and strengthen disarmament and arms control processes is greater than ever. I urge the leaders of Russia and the United States to work together in the common interests of peace and humanity.”last_img read more

French fuel fight Prime minister offers to meet protesters

first_imgPARIS — France’s prime minister is offering to meet with members of a motorists movement who have blocked roads over rising fuel taxes and held protests that caused damage to central Paris.Prime Minister Edouard Philippe said on BFM television Wednesday that the protesters are expressing “a lot of legitimate things that should be heard.”The drivers may ignore the outreach. Some are calling for a new action Saturday on the Champs-Elysees in Paris, where a protest last Saturday degenerated into violence.The drivers denounce perceived elitism by President Emmanuel Macron, who failed to defuse the anger with a speech Tuesday explaining the environmental need for the tax hikes.Protesters shouted at the minister for overseas territories, Annick Girardin, as she sought to calm tensions Wednesday on the Indian Ocean island of Reunion, where demonstrations have been particularly violent.The Associated Presslast_img read more

Rep Markkanen announces Outstanding Educator Award recipients

first_img14May Rep. Markkanen announces Outstanding Educator Award recipients Categories: Markkanen News State Rep. Greg Markkanen announced today the 2018-2019 Outstanding Educator Award recipients.The award winners are Luke Theisen of Horizons Alternative High School, Laura Augustine of L’Anse Area Schools, and Heather French of Lake Linden-Hubbell Schools.Luke Theisen has been vital in the creation of Horizon’s “Student First Initiative,” a program that aims to strengthen the student body by decreasing stressful factors, promoting attendance and reducing discipline referrals. Theisen has taught English for the past 10 years.Heather French has gone above and beyond the call of a typical teacher. French has been known to help with assisting students with tough life events, helping out with scholarship applications, and even helping prepare students for prom. She teaches English in grades 7-9.Laura Augustine has been involved in the L’Anse community in multiple ways. Augustine has organized the annual Variety of Music Show, led students on numerous trips oversees, and organized the L’Anse Literacy Club. She has also been the choir director at L’Anse United Methodist Church for over 25 years. Augustine has received awards including Outstanding Education Employee from the Copper Country Association of School Boards and the Distinguished Educator Award. She has taught English and study skills for over 20 years.last_img read more

Apples fourth generation Apple TV box Apple is re

first_imgApple’s fourth generation Apple TV boxApple is reportedly testing a fifth generation version of Apple TV that will support ultra high definition content.According to Bloomberg, the update could be released as early as this year with the device able to stream 4K resolution pictures and “more vivid colours”, implying high dynamic range capabilities.The new box will run on a faster processor than the current generation of Apple TV and is being referred to internally as ‘J105’, the report said.The news comes in the same month that Apple appointed the director and general manager of Amazon’s Fire TV product, Timothy Twerdahl, to work on Apple TV.Twerdahl, who has also previously worked for Roku and Netflix, confirmed his new role as a VP at Apple on his LinkedIn profile. It is understood that he will report to iPhone marketing VP Greg Joswiak.Separately, Apple’s SVP of internet software and services, Eddy Cue, confirmed at a conference this week that Apple’s first original TV programmes – Carpool Karaoke and Planet of the Apps – will launch on Apple Music in the “next few months”.Cue said that Apple has a “real opportunity in the TV space” but is interested in doing programmes that aren’t being done by anyone else – ones that take advantage of its platforms.On Apple’s most recent earnings call, CEO Tim Cook said that he expects Apple’s participation in the television space to accelerate as the cable bundle begins to break down, with its Apple TV set-top providing a firm grounding for doing so.“We started the new Apple TV a year ago, and we’re pleased with how that platform has come along. We have more things planned for it but it’s come a long way in a year, and it gives us a clear platform to build off of,” said Cook.last_img read more

Facebook has put one of its key executives Andrew

first_imgFacebook has put one of its key executives, Andrew Bosworth, in charge of the company’s consumer hardware activity and is planning to launch a new video chat devices codenamed Aloha, according to a report by Business Insider.According to the report, Aloha will be the first in a series of consumer devices from Facebook’s CE team, which is also working on a smart speaker, a 360° camera and wearables.Aloha, it said, will feature a large touchscreen and camera as well as face recognition technology.According to Business Insider, Bosworth, previously vice-president of Facebook’s ads and business platform, will now head up all consumer hardware activities, including both the Oculus virtual reality arm and activities carried out in ‘Building 8’ a secretive facility dedicated to new programmes.According to the report, Facebook is attempting to unity its disparate hardware efforts in order to better compete with the likes of Apple, Google and Microsoft.Business Insider said that Facebook’s Building 8 has suffered from a number of high-profile departures in recent months, including those of chief operating officer Richard Wooldridge, head of consumer experience Donald Hicks and head of product management Olivier Bartholot.last_img read more

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first_imgSponsor Advertisement We’re still sitting here with nothing resolved…especially with the hideous and grotesque short positions in both gold and silver still in place.It was pretty quiet during Far East trading on their Monday. The high of the day was in shortly after 2:00 p.m. Hong Kong time…about fifty minutes before the London open…and it was all down hill until fifteen minutes after the Comex open in New York.The subsequent rally got capped…and then got sold off once the London p.m. gold fix was in at 3:00 p.m. BST…10:00 a.m. in New York..Gold closed at $1,709.80 spot…down $1.30 from Friday…and volume was anemic at 60,000 contracts, as most traders stayed home in advance of mega-hurricane Sandy.The silver chart looked identical to the gold chart.  Silver’s high tick came minutes after 10:00 a.m. Hong Kong time…but after that, silver’s price path was a carbon copy of gold’s.Silver finished the Monday trading session at $31.76 spot…down 33 cents on the day.  Volume was also very light…around 17,500 contracts.The other two precious metals got sold off as well.  It’s worth noting that even though the equity markets were closed…the precious metal and currency markets remained open.The dollar index closed at 79.997 on Friday…and worked its was slowly higher in fits and starts on Monday…closing at 80.23.  The high tick…30.31…came during the New York lunch hour.With the New York markets closed, there was no HUI…but the TSX Gold index here in Canada closed up just under a percent.Of course there was no Silver Sentiment Index either…but just eye-balling the silver stocks that I follow here in Canada on the Toronto Stock Exchange, I’m guessing that the silver stocks were down about a percent on average.The CME’s Daily Delivery Report showed that 8 gold and 24 silver contracts were posted for delivery within the Comex-approved warehouse system on Wednesday.  In silver, it was all the “usual suspects”…and that should just about be it for the October delivery month.  Tomorrow evening the CME should post the numbers for the November delivery month…and I’ll have that data for you on Wednesday.  The link to yesterday’s Issuers and Stoppers Report is here.Not surprisingly, there were no reported changes in either GLD or SLV…and the U.S. Mint had no sales report, either.The updated short positions for GLD and SLV were posted on the shortsqueeze.com Internet site late last week.  In silver, it showed that the short position jumped by 25.45%…from 11.65 million shares/ounces, all the way out to 14.62 million shares/ounces…454.7 tonnes.  It’s a good bet that an authorized participant shorted the shares rather than deposit real metal…which they didn’t have. They could have found it somewhere, I’m sure…but how high would they have had to bid the silver price to get it all?The short position in GLD actually declined by 6.54%…from 18.18 million shares, down to 16.99 million shares…or 1.70 million ounces…52.9 tonnes.The Comex-approved depositories reported receiving 596,425 troy ounces of silver on Friday…and didn’t ship any out.  The link to that activity is here.Being Tuesday, I have more than the usual compliment of stories…and I hope you can find the time to go through them all.  As usual, the final edit is up to you.Nor is the pressure to hold PHYSICAL Gold confined to the central banks. A trader in the city of London has an explanation of why Gold holdings in Exchange Traded Funds (ETFs) have not kept up their previous momentum in the period since 2004-2009. He says that “some investors” have moved from being comfortable with paper claims to Gold to a position where they are not confident unless they hold the physical metal itself. Nothing could be more probable. – Bill Buckler…Gold This Week…27 October 2012Well, I wouldn’t read a whole heck of a lot into yesterday’s trading action in all four precious metals.  But it was interesting to note that they followed their usual price paths…and they were all down on the day as well…plus the fact that they were trading at all, when the rest of the markets in New York were closed.  I guess JPMorgan et al never sleep when it comes to the price management scheme.Of course we’re still sitting here with nothing resolved…especially with the hideous and grotesque short positions in both gold and silver still in place.Today, at the close of Comex trading, is the cut-off for this Friday’s Commitment of Traders Report…and unless there are some big changes in price tomorrow I’m not expecting big changes in the COT Report either…as it has been a reasonably quiet week from a price point of view.By the way, I didn’t hear from anyone at Scotiabank or Scotia Mocatta yesterday, so they’ll be getting another request for an answer when I get out of bed later this morning.Not much happened in Far East trading on their Tuesday…but now that London has been open for a couple of hours, both metals are trading up from Monday’s close…a lot of which would have to do with the dollar index slide back to the 80.00 level.  Volumes, which had been pretty light at the London open, are now a bit more chunky, but nothing out of the ordinary…and it does appear from the price action that these rallies [as tiny as they are] are being met by the usual not-for-profit sellers.Before heading off to bed, I thought that some of you might be interested in this special sale [50% off the regular retail price] that Casey Research is having on the Casey Extraordinary Technology monthly report.Casey analyst Alex Daley has made a career of finding and monetizing big ideas….In fact, this was his main job when he worked for an elite team of technologists that reported to the CEO of one of America’s largest corporations. His group released some of the first smartphone apps, social networking sites and even did projects for large oil companies.But today Alex says he’s putting his money into a radical new technology that will soon make its way into millions of homes and offices across America and is expected to generate $3.7 billion in sales by 2015.Casey Research has recently made a video detailing his latest insights, including how you can take a position in this technological breakthrough right now. If you’re at all interested, click here to learn more.  This offer is only open until the end of tomorrow…Hallowe’en…and there are no tricks involved.  As a matter of fact, it’s my belief that Casey Research‘s standard 90-day guarantee of satisfaction applies.  How can you lose?That’s more than enough for one day…and it’s actually too much for one day, so I hope you were able to edit it to your satisfaction.See you tomorrow. Former Microsoft Inventor Reveals Big Tech WinnersFrom smartphone apps… to self-driving cars… to facial recognition software… Alex Daley and his team at Microsoft helped bring to market some of the most popular technologies of the past decade.In the process, Alex developed an uncanny knack for picking winning disruptive technologies, helping venture capitalists realize extraordinary gains. Now he’s identified a radical new technology that he expects to generate $3.7 billion in sales by 2015.All the details are in his new video – click here to see it now (it may not be up long, so please view it today).last_img read more

Several states are questioning the cost of using p

first_imgSeveral states are questioning the cost of using pharmacy middlemen to manage their prescription drug programs in a movement that could shake up the complex system that manages how pharmaceuticals are priced and paid for.The debate is playing out this week in an Ohio courtroom, as the state fights to release a report detailing what it paid two middlemen, CVS Health and Optum, to manage its Medicaid program’s prescription drug plans.The report shows that the companies charged the state 8.8 percent more than they paid to pharmacies to fill prescriptions. The companies kept the more than $224 million difference between what they charged the state and paid for the drugs.”I would love to tell you that 8.8 percent is too high, too low, or normal, but I’m really unqualified to say that because our state Medicaid program is the first state in the country to really get this level of transparency into how this works,” says Antonio Ciaccia, the director of government affairs for the Ohio Pharmacists Association.But he added, “I think 8.8 percent is insane.”Ohio’s Medicaid program is run almost completely through private managed care insurance companies. Those companies in turn contract with CVS Health and Optum to manage the prescription drug portion of recipients’ coverage. The companies — known as pharmacy benefit managers, or PBMs — negotiate discounts from drugmakers and work hard to keep the prices they actually pay secret.Ciaccia says that independent pharmacists became alarmed because their reimbursements from the two companies plummeted in recent years. He and a partner started a company, 46 Brooklyn, specifically to analyze drug prices and found that pharmacists were being paid sometimes only a fraction of what the middlemen were charging states.For example, Ohio paid the PBM $273.50 per unit for the generic version of Gleevec, a drug that treats leukemia and other cancers, while pharmacies reported the wholesale price of the drug was $83.69. In other words, the PBM charged the state more than the three times the price of the drug.Ohio’s Department of Medicaid commissioned its own analysis of its prescription drug program costs after the Columbus Dispatch newspaper reported the program was spending far more for prescription drugs than the pharmacies that filled those prescriptions were receiving.Last month the state released a summary that revealed the two companies were keeping 8.8 percent of the pharmacy budget. But when the state said it planned to release the entire report, CVS sued to stop it. Optum joined the suit this week and at a hearing Tuesday a judge told the companies to identify any trade secrets they want redacted by next month.Ohio Medicaid spokesman Tom Betti said in a statement that the state is committed to releasing the findings.”Transparency is not only the duty of government to its owners—the people of Ohio—but it’s also essential for the market to function properly. We believe this deeply and will continue to pursue it,” the statement said.If the analysis is released, it will offer an unprecedented look into the opaque world of pharmacy benefit managers and the mechanics of drug pricing.The findings in the analysis have angered state officials and Attorney General Mike DeWine has threatened to sue.”It is clear that the conduct by PBMs in these areas remains a major concern, and we anticipate that our investigation will result in major litigation against PBMs,” he said in a statement.CVS Health spokeswoman Christine Cramer pointed out that Ohio’s report concluded that the company saved the state about $145 million compared to an alternative system where the state pays a fee for each prescription filled.And she said releasing the report would hurt the company’s ability to negotiate low prices.”When it comes to the proprietary rates and formulas we use to negotiate for lower drug prices or cost-effective dispensing within our pharmacy network, making those figures public only hurts our ability to negotiate the lowest rates and fees in a highly competitive market, which would ultimately cost the state and the taxpayers more,” she said in a written statement.Optum did not respond to calls and emails for comment.”I think that Ohio is going to have an uphill battle when it comes to releasing this information,” says Stacie Dusetzina, a professor of health policy at Vanderbilt University School of Medicine. “It’s going to be fought very hard by CVS because they think it would set a standard for transparency and providing the public with this information.” She adds that efforts in other states to reveal drug pricing secrets have failed.Ohio isn’t alone in questioning the value of using middlemen to manage their prescription drug plans.States spend more than $33 billion a year on prescription drugs through their Medicaid programs and for many, that’s the fastest growing part of the Medicaid budget. So efforts to control those costs are front and center in many state budget debates.West Virginia last year stopped using pharmacy benefit managers altogether. And Kentucky is also doing an analysis of its costs while lawmakers consider legislation that would require pharmacy benefit managers that contract with Medicaid to report details of their costs to the state and ensure they pay independent pharmacies a fair price.And In Iowa, State Representative John Forbes — who’s also a pharmacist — launched his own investigation into a county government health plan a few months ago after hearing complaints from pharmacists.”We went through the records for this county over about a three-month period and found that, in many cases, the pharmacies were being paid $5 to $10 for prescriptions, but the county entity was being billed over $100 for those same prescription medications,” Forbes said in an interview.He says the oversight committee in Iowa’s legislature now plans to investigate the PBM’s practices. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Study analyzes vaccinepreventable infections in children who receive solid organ transplants

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 15 2019Children who receive solid organ transplants are hospitalized due to vaccine-preventable infections at rates that are significantly higher than the general population, according to a newly published study by University of Colorado School of Medicine researchers.The study, published today in JAMA Pediatrics, reviewed nearly 7,000 transplant recipients nationally over a seven-year period beginning Jan. 1, 2004, to determine how often they are hospitalized with infections that are typically prevented with vaccines.Of the 6,980 transplant recipients in the study, 1,092 patients, or 15.6 percent, were hospitalized with a total of 1,490 cases of vaccine-preventable infections within five years after transplant surgery. At that rate, hospitalization among the transplant population was up to 87 times higher than in the general population.Related StoriesMore effective flu vaccine begins clinical trials across the U.S.Researchers develop improved vaccine for meningitis and bloodstream infectionsVaccine drama on display in California’s Capitol”The huge burden of illness from vaccine-preventable infections that we show in this article should stress to all physicians the critical importance of ensuring that all transplant patients receive age-appropriate immunizations,” said the study’s lead author, Amy Feldman, MD, MSCS, assistant professor of pediatrics for the CU School of Medicine and program director for the liver transplant fellowship at Children’s Hospital Colorado on the Anschutz Medical Campus.While other studies have looked at morbidity from certain types of infections, this study is the first to explore the burden of illness from all vaccine-preventable infections across the entire pediatric solid organ transplant population. The analysis included all patients younger than 18 years old who underwent a heart, lung, liver, kidney, intestine, or multivisceral transplant at any of the 45 U.S. not-for-profit tertiary care pediatric hospitals that report data to the Pediatric Health Information System of the Children’s Hospital Association.Based on the findings, Feldman and her co-authors recommend further study to identify ways to improve the likelihood of vaccination among children who need transplant surgery. The goal is to reduce the costs of hospitalization and the rates of sickness and death due to infections that could be prevented by vaccination. Source:http://www.ucdenver.edu/last_img read more

Lowlevel cannabis use can change the adolescent brain

first_imgAnalyzing data from a large research program investigating adolescent brain development and mental health, Catherine Orr and colleagues identified brain regions rich in cannabinoid receptors that underwent structural changes in teenagers who reported limited cannabis use. These differences persisted despite controlling for many variables, including sex and socioeconomic status as well as alcohol and nicotine use, and were only apparent after cannabis use. Finally, the researchers demonstrate associations between increased grey matter volume in low-level cannabis users and assessments of reasoning and anxiety.Given the important role of the endogenous cannabinoid system in brain development during adolescence, teenagers may be particularly vulnerable to the effects of THC, the primary psychoactive component of marijuana. Additional research is needed to determine whether these findings apply to more diverse populations beyond the four European countries studied here.Source: http://www.sfn.org/ Jan 16 2019Teenagers who report using recreational marijuana just once or twice display increased volume of numerous brain regions, according to a study of 14-year-olds from Ireland, England, France, and Germany. The research, published in JNeurosci, warrants further study of low-level cannabis use among adolescents amid changing societal attitudes toward the drug.last_img read more

Study shows benefits of including red raspberries in the diet of people

first_img Source:https://web.iit.edu/ Reviewed by James Ives, M.Psych. (Editor)Feb 26 2019A study released today from the Illinois Institute of Technology shows the benefits of including red raspberries in the diet of individuals with pre-diabetes and insulin resistance.According to the Centers for Disease Control and Prevention (CDC), an estimated 34 percent of American adults, around 84.1 million in all, had prediabetes in 2015. Patients with prediabetes are at higher risk for a number of conditions – including developing type 2 diabetes, cardiovascular disease and Alzheimer’s disease.The study, published in Obesity, investigated the effects of red raspberries in a group of people at-risk for diabetes who were overweight or obese and presented with prediabetes and insulin resistance. A metabolically healthy control group was also included in the study for reference.Related StoriesIntermittent fasting may protect against type 2 diabetesDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesNew biomaterial could encapsulate and protect implanted insulin-producing cellsUsing a randomized, controlled, acute study design, 32 adults between the ages of 20-60 years had their blood tested over a 24-hour period after eating breakfast on three separate days. The three breakfast meals were similar in calories and macronutrients, but differed in the amount of frozen red raspberries – one meal contained no raspberries, one contained one cup of raspberries and one contained two cups of raspberries.The results showed that as the amount of raspberry intake increased, individuals at risk for diabetes needed less insulin to manage their blood glucose. When two cups of red raspberries were included in the meal, glucose concentrations were lower compared to the meal with no red raspberries. The data suggests that simple inclusion of certain fruits, such as red raspberries with meals, can have glucose lowering benefits with indications of improvements in insulin responses. These effects are particularly important for people who are overweight or obese with pre-diabetes.”People at risk for diabetes are often told to not eat fruit because of their sugar content. However, certain fruits – such as red raspberries – not only provide essential micronutrients, but also components such as anthocyanins, which give them their red color, ellagitannins and fibers that have anti-diabetic actions,” said Britt Burton-Freeman, Ph.D., director, Center for Nutrition Research at Illinois Tech. “For people who are at risk for diabetes, cardiovascular disease and other health risks, knowing what foods have protective benefits and working them into your diet now can be an important strategy for slowing or reversing progression to disease.”last_img read more

Researchers unravel the biology of how obesity promotes triplenegative breast cancer

first_img Source:https://www.uchicagomedicine.org/ Reviewed by Alina Shrourou, B.Sc. (Editor)May 7 2019Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has been gaining ground. A new study from researchers at the University of Chicago finds that women with breast cancer, the most common cancer among women, are at even higher risk from obesity.Breast cancers occur in adipose tissue, better known as fat. Triple-negative breast cancer (TNBC) is a type of breast cancer that is particularly difficult to treat. None of the three most appealing drug targets — the estrogen receptor, the progesterone receptor and human epidermal growth factor receptor 2 — are present on TNBC cells.”These cancers can be particularly aggressive,” said study author Lev Becker, PhD, an assistant professor in the Ben May Department for Cancer Research at the University of Chicago. “For patients with TNBC, there are few therapeutic options. The survival rate is quite low. And the cancer tends to be dramatically elevated in patients who are overweight or obese.”Obesity has become “a global epidemic,” Becker said. The prevalence in the United States is about 36 percent for ages 20 to 39, 43 percent for ages 40 to 59, and 41 percent for those 60 and older. The United States is ranked 12th worldwide for obesity.”Current treatment of breast cancer patients ignores the ongoing obesity epidemic,” said study co-author Marsha Rosner, PhD, the Charles B. Huggins Professor in the Ben May Department for Cancer Research. “In order to take this into consideration, we need to help patients lose weight or identify new drug targets that would be effective in obese cancer patients.”Unfortunately, once the cancer has been detected there may not be time to lose weight prior to treatment. “So our bottom line,” Rosner said, is to “promote weight loss as a cancer prevention measure, incorporate weight loss as a component of therapy for patients with breast cancer, and develop specific drug targets that could be leveraged to address the obesity component of the disease.”Related StoriesStudy reports role of cancer gene in tumor microenvironmentHarnessing target of the brain chemical serotonin to combat obesityBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryIn their paper, “Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer,” published May 3, 2019 in the Journal of Experimental Medicine, Becker, Rosner and colleagues unravel the biology of how obesity promotes TNBC. They show that obesity reprograms macrophages — scavenger white blood cells that can devour invaders such as bacteria, viruses or tumor cells — into pro-inflammatory, metabolically-activated macrophages. Instead of fighting breast cancer, these immune cells actually promote it.”Our studies, in mice and humans,” Becker added, “implicate these metabolically-activated adipose tissue macrophages.” They accumulate in mammary adipose tissue. They release interleukin 6, a pro-inflammatory cytokine which can fuel tumorigenesis. And they thrive on obesity.Interleukin 6 binds to a receptor on the surface of existing cancer cells. That can create “an even more aggressive stem cell phenotype,” Becker said. “These cancer stem cells are able to encourage tumor growth and metastasis, enabling them to travel to other sites.” Patients with advanced or metastatic cancer have higher levels of IL-6 in their blood, which is correlated with poor survival rates.Obesity, the study authors wrote, is a pathological state that “facilitates tumorigenesis by creating tumor permissive conditions in multiple tissues.” This suggests that chronic inflammation and its effects on tumorigenesis may be reversed by targeted anti-inflammatory therapies or by weight loss. Indeed, the researchers found that inducing weight loss in obese mice by feeding them a healthier low-fat diet reversed macrophage inflammation and TNBC tumor formation in mammary fat, even though their body weight remained elevated. These findings highlight the potential value of weight loss, not only as a preventive intervention but even after patients develop breast cancer.last_img read more

Amazons digital ad business surpasses Microsoft Yahoo report says

first_img Explore further Amazon’s U.S. digital advertising business is likely to bring in $4.6 billion in 2018, from an estimated $1.8 billion a year ago, eMarketer said.Amazon doesn’t break out sales from advertising, which it reports alongside other lines of business in an “other” category on its financial reports. That segment recorded $2.1 billion in sales during Amazon’s most recent quarter, more than double the year-earlier figure.Amazon has sold ads on its retail websites and on specific product search results for years. But that business began to take off recently with a perception among some ad buyers that Amazon, with its data on what people buy, can help them more precisely determine whether people bought something after seeing advertisements.”People are switching much of their purchasing to online channels, which Amazon is of course driving and benefiting quite heavily from,” said Monica Peart, senior forecasting director of eMarketer. Amazon is also reaping the rewards of an increase in product searches started on the retailer’s website, instead of on Google or another search engine, she said.Google will take in $41 billion in digital ad revenue in the U.S. in 2018, eMarketer estimates, and Facebook $22.8 billion.Amazon was just ahead of rival Microsoft, which, including its LinkedIn professional social networking arm, will post digital ad revenue of $4.5 billion this year, eMarketer estimated. In fifth place is Oath –– the Verizon-owned grouping of AOL, Yahoo, and other early web stalwarts –– which will take in $3.6 billion. Amazon.com’s advertising business is likely to more than double its sales in the U.S. this year, a market researcher said Wednesday, which would place the company behind only Google and Facebook. Amazon muscles in on Google’s and Facebook’s advertising turf ©2018 The Seattle Times Distributed by Tribune Content Agency, LLC. Citation: Amazon’s digital ad business surpasses Microsoft, Yahoo, report says (2018, September 24) retrieved 17 July 2019 from https://phys.org/news/2018-09-amazon-digital-ad-business-surpasses.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more