Barcelona puts price on striker wanted by West Ham

first_imgThe English side would have to pay up to 3 million Pounds if they want Paco Alcácer to join them this season; would only be a loanPublished by the Daily Star in the United Kingdom, there have been reports that Spanish powerhouse Barcelona have put a price on striker Paco Alcácer if he wants to join the Premier League.The forward could end up costing up to 3 million Pounds to English club West Ham United, but will only join the competition on a loan.The 25-years-old has been a surplus in Barcelona, playing only 37 times in La Liga in over two years at Barca.David Villa, SpainQuiz: How much do you know about David Villa? Boro Tanchev – September 14, 2019 Time to test your knowledge about Spanish legendary forward David Villa.His goal scoring abilities are not playing in his favor either.In 37 occasions on the field, the player has only scored ten times during the Spanish competition, with four more goals coming from the Spanish Cup and only once in the Champions League.But it seems the ex-Valencia and ex-Getafe athlete will only exit Barcelona if West Ham pays 3 million Pounds for his loan, something the English club might not be too keen on doing.last_img read more

I am giving my all Radja Nainggolan

first_imgThe Internazionale Milan footballer is happy after his team beat Fiorentina last night and talks about what he wants in the futureInternazionale Milan beat Fiorentina 2-1 yesterday in Matchday 6 of the Italian Lega Serie A season.And Radja Nainggolan couldn’t be any happier, after spending his first few months under the Inter shirt.“I am giving my all during this new adventure. Obviously, I still have to improve considering I missed out on preparations and I will show that little bit extra to reach the top,” he told the club’s official website.“However, I am not worried. I felt at ease here at Inter straight away. I was welcomed into the club with open arms. I am happy to be here and I hope it’s a successful period. Our main aim this year is to improve on last season.”“We didn’t start in the best manner, but our last two wins have put us back on track. We hope to now continue like this. The road is long, but we’ve won two important games and we must keep moving forward in the same fashion,” he added.“There are plenty of expectations on us but we’ve demonstrated that we can win tough matches. We are a strong side.”Romelu Lukaku, Serie A, Inter MilanCapello calls Lukaku “a modern striker” Manuel R. Medina – September 14, 2019 The former Italian manager believes Romelu Lukaku is perfectly suited for Antonio Conte’s Internazionale Milan in the Serie A.“I want to win trophies, that is obvious. I’ve always given my all out on the pitch but it’s now the right time to win something. However, we’ll keep our heads down. It’s better to say nothing and then see where we are at the end of the season,” he concluded.Altra vittoria a San Siro! 👏Riviviamo tutto insieme con la nostra fotogallery 📸👉 https://t.co/TqrQ3GELEw #FCIM pic.twitter.com/nJRH4XWpYd— Inter (@Inter) September 25, 2018last_img read more

Scotia Bank Plans to Close 120 Branches Worldwide

first_img New small business support organization established Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:branch close, cecil arnold, Scotia bank ‘Positives’ for HIV/Aids down in Turks and Caicos; Testing today Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 5 Nov 2014 – ScotiaBank is planning to close 120 banks around the world and cut back on as many as 15,000 staff. The announcement caused quite a raucous in the financial world yesterday, especially as talk was that the Caribbean branches of Scotiabank are not performing as well as they used to do. We picked up on an exchange on the Business News Network via the Globe and Mail; where it was said three major loans in the Caribbean had to be written down; the region called troublesome for ScotiaBank and RBC. We contacted Managing Director of ScotiaBank Turks and Caicos Ltd, Cecil Arnold who expeditiously responded with: There are no known impacts to Scotiabank TCI staff or its current operations, no impact on borrowing or our current employees. These decisions are being made to improve the bank’s overall efficiencies in Canada and its international banking operations. We will remain the most international of the Canadian banks, fully committed to our employees and customers.” Mr Arnold pointed out that ScotiaBank has two million Caribbean customers and 19 banks in the region. ‘Know Your Status’ as ScotiaBank supports Regional HIV Testing daylast_img read more

Holland England must change to win major tournaments

first_imgEngland assistant manager Steve Holland believes that they must be brave and attempts changes or else they will continue to come short in major tournamentsThe Three Lions’ sole major honour in football comes from the 1966 World Cup where they won at home led by the legendary Sir Bobby Charlton.Since then, the closest England have ever come to glory in a major international competition comes from two more semi-final appearances in the World Cup and another in Euro 1996.Holland, who was a part of Gareth Southgate’s coaching staff at the 2018 World Cup, believes the national side have made progress following their last four appearance at Russia.But the former Chelsea assistant coach admits England need to take a bold approach if they are to succeed on the big stage.“When you reflect on the World Cup as a whole, we definitely made progress but we weren’t perfect,” said Holland, according to the Telegraph.“Gareth’s mantra from the start, particularly given his own personal experience, is that he’s not afraid of trying things.Jadon Sancho, Borussia DortmundCrouch: Liverpool could beat Man United to Jadon Sancho Andrew Smyth – September 14, 2019 Peter Crouch wouldn’t be surprised to see Jadon Sancho end up at Liverpool one day instead of his long-term pursuers Manchester United.“I don’t mean to be critical of any England team or any England manager in recent history, but the fact of the matter is, I’m 48 and I’ve never seen England in a final.“I’ve only seen England in two semi-finals up until this summer so although we are a proud footballing nation, the reality is we have not been very good on the big stage.“If we were to continue along the same lines as history then maybe we’d get the same outcome. So there was a need to look at things differently and not be afraid to try.“That’s really come from Gareth which is not as easy to do as it is to say. The challenge was not just to do OK and keep the pressure off, the challenge is to win and although the summer was good we didn’t want. And we felt we might be able to adjust it to increase the chances of winning.”England will be competing in the semi-finals of the UEFA Nations League this summer with the Netherlands awaiting them on June 6 in Guimarães, Portugal.The other semi-finalists for the competition are hosts Portugal and Switzerland.last_img read more

Audi launching 30 electrified vehicles by 2025

first_img More From Roadshow Following the launch of the E-Tron SUV this spring, Audi will bring the E-Tron Sportback — likely called E-Tron Performance — to market. It packs all the goodies of the standard E-Tron in a sort of crossover-coupe shape. In other words, it’s an E-Tron SUV with a more heavily raked roofline and slightly wider proportions.In 2020, Audi will launch the Q4 E-Tron, which rides on the Volkswagen Group’s MLB Evo electric vehicle architecture. As we reported earlier, the production Q4 E-Tron will look remarkably similar to the concept car, the production Q4 E-Tron will look remarkably similar to the concept car from this year’s Geneva Motor Show, right down to the funky, customizable LED running lights.The E-Tron GT will also arrive in 2020, and will share a number of its components with the upcoming Porsche Taycan, including a new, 800-volt charging system. Much like the Q4 E-Tron, the production GT will bear a striking resemblance to the concept from last year’s Los Angeles Auto Show, though it, too, will gain real door handles and a bit more texturing around the front fascia.Early next decade, a number of electrified Audis will launch on the company’s new PPE architecture, co-developed with Porsche. It’s unclear exactly what Audi has in store for this PPE platform, but Porsche has already confirmed the next-generation Macan SUV will use this electrified base. 51 Photos 26 Photos Audi’s new E-Tron electric SUV will hit the road in the US in the coming months. It’s a big step forward for the German automaker’s electrification plans, but as it turns out, it’s only the tip of the iceberg.At an event at Audi’s headquarters in Ingolstadt, Germany, on Wednesday, company executives confirmed the brand will launch 30 electrified vehicles by the year 2025. The key word here is electrified — as in, not necessarily fully electric. Cars like the recently announced A6, A7, A8 and Q5 plug-in hybrids count toward this 30-vehicle goal. 2018 Audi Q7: Rockin’ the suburbs 0 2018 Audi S4: The sweet spot sport sedan Audi E-Tron GT concept on the streets of Los Angeles Electric Cars Luxury cars Audi Share your voice Post a comment Tags 2019 Audi E-Tron basking in the desert sun 2019 Audi Q8 review: Stop worrying and love the roof Audilast_img read more

Last session of 10th parliament prorogued

first_imgThe last session of the 10th Parliament was prorogued on Monday after only eight sittings.The 23rd session passed 19 bills, including the Narcotics Control Bill, 2018 and Sarkari Chakori Ain 2018.Speaker Shirin Sharmin Chaudhury read out the prorogation order of the president around 10:05pm.Before reading out the prorogation order, Shirin thanked all the MPs, including the opposition ones, for providing all-out cooperation in running the session and reaching a consensus in a unique way to uphold the parliamentary democratic practice in the house.She said parliament got lively with the active participation of the MPs of both the treasury and opposition benches.The speaker praised the opposition MPs for their constructive role in the session by joining different businesses of the house.Parliament during its current tenure sat 23 times that witnessed 410 business days. Some 198 bills were placed and 193 of them were passed.The opposition did not boycott parliament, but they staged walkout for three times, while the opposition leader was present in the house for 242 days.Leader of the house and prime minister Sheikh Hasina was present in the 10th parliament for 338 days.last_img read more

DCs Central Library Closes for Modernization

first_imgIn preparation for a major modernization effort, D.C. Public Library Executive Director Richard Reyes-Gavilan announced on Feb. 3, that the Martin Luther King Jr. Memorial Library will close on March 4. In addition to providing a final rendering and floor plan of the proposed changes, Reyes-Gayilan, offered an update on management of services for the city’s central library location.Once reopened, the new MLK Library will offer magnificent views of the downtown D.C., as well as new technology hubs, theaters and shops. (Courtesy photo)Construction on the Martin Luther King Jr. Memorial Library will start in the summer of 2017 and continue until 2020. When the $208 million transformation is complete, the library will become the center of activity for the already vibrant downtown area. The building will feature a new, transparent entryway and sculptured stairs. Public art will be solicited for the reading room, the vestibule, and the plaza in front of the building. The art installations in the vestibule and the plaza will honor Dr. King.The closure, said Gayilan, should be relatively smooth, with historical documents and other resources parceled out to other library locations and sites across the city. “We will be looking to make access to those [Washingtonian] collections used most frequently, and while we don’t have a written [memorandum of understanding] in place, we are excited about the possibility of having the Historical Society [of Washington] serve as a temporary location for some of our staff,” Gayilan told the Washington Post.Neighborhood libraries, currently closed on Thursday mornings, will open at 9:30 a.m. A retail location, “Library Express” opens at 1990 K St. NW to house the Adult Literacy Resource Center and Center for Accessibility as well as provide a small browsing collection of books and public access to computers. The labs, which include the Fabrication, Memory, and Studio labs, will be modified and relocated.The Memory Lab will be housed at the Northeast Library, 330 7th St. NE. Fifty laptops will be dispersed to neighborhood libraries to accommodate increased traffic.Jacintha Gray, a graduate student examining the orphanages in the District between the turn of the century and 1920, said she is excited about the changes, and remains hopeful that she can continue her research at one of the other locations. “The overhaul is necessary and is obvious to anyone who utilizes the library for concentrated research. From the elevators to the bathrooms, the whole facility turns into trying to navigate homeless people, and trying to get comfortable in less-than-inviting surroundings,” Gray told the AFRO. “This move by the library executives and the community at large, shows their commitment to making the facility conducive to real learning.”More than 70 community meetings and 13 focus groups were held across the city, hundreds of surveys submitted, and more than 4,000 people were reached in person or online. The project has been approved by the National Capital Planning Commission, the Historic Preservation Review Board, and the U.S. Commission of Fine Arts.As a final endeavor, on March 3, the library will screen the documentary “A Legacy of Mies and King.” This film follows architect Francine Houben, creative director of Mecanoo Architecten, as she delves into the archives, meets contemporaries of Ludwig Mies van der Rohe, who designed the library, and King, speaks to current library visitors and participates in the District¹s Martin Luther King Jr. Day parade, to better envision the new building.last_img read more

Crooning of love

first_imgHe took the country by storm with his soothing voice when he sang Mitwa in Kabhi Alvida na Kehna. By then he was already a favourite of music  lovers with songs like Mora Saiyyan mohse bole na and Aankhon ke saagar which he performed in the Pakistani band Fuzon.  The man with the golden voice, Shafqat Amanat Ali Khan talks to Naila Manal about his newly released album Muhdikhai…Tell me about your musical journey.I was born in a musical family so music wasn’t something new to me.  We had seven generations of musicians. I was a part of the Pakistani band Fuzon (as the lead singer). I bumped into the band members when I was in Karachi. Also Read – ‘Playing Jojo was emotionally exhausting’When we came up with the album Saagar, which had the song Aankhon ke Saagar, two of my songs were used by Nagesh Kukunoor in his film. Shankar (Mahadevan) called me and signed me. There has been no looking back since.But as far as my overall journey is concerned it has been great so far.  I am coming up with an album Muhdikhai…Unveiling the songs of eternal love. This is my fourth album and my third solo album. My journey has been productive so far. I have learnt a lot, experienced a lot and in the midst of it all distributed and shared a lot too. Also Read – Leslie doing new comedy special with NetflixYou came up with your new album Muhdikhai… Unveiling the songs of eternal love recently. Tell me more about it.For quite some time my fans have been demanding an album. Personally, I also wanted to go back to the studios and work. But films and other engagements, especially travelling gave me no time. Baith ke kaam karne ka waqt nahi tha (I didn’t have time to sit and work for the album), but one day I decided. It somehow came by and I started enjoying returning to the studio and recording. I really enjoyed it all, mazaa aya. My album hits stores on March 20. How is coming out with an album different from say, singing a song in a film, or performing in a band?It’s about the joy of creation, the difference between contributing to someone else’s work and creating something all by yourself. Film music is a collective effort and you are a part of someone else’s vision. Here, I was taking care of everything from the music to production and I had to oversee every intricacy. From a raw idea to a final productive, it is all mine, however it is. How is it for you to perform in India?India is like a second home to me. I get so much love here. In fact I have been lucky to get love everywhere lekin yahan aur jagaah ke muqaable zyada pyaar milta hai (I get more love here than anywhere else). Which is your favorite song among all those you have sung?You should pose this question to someone else. All I can say is I perform all my songs with all honesty.Ok, so which is your all time favourite song?That would be Tere Bina Zindagi se koi shakwa nahi.Who is your inspiration?My father, I have always wanted to be like him, sing like him, look like him.  He is my inspiration. It is a compliment for me if someone says that I sound like him.last_img read more

30yearold youth assaults minor at Basanti

first_imgKolkata: An eight-year-old minor girl from Basanti in South 24-Parganas was allegedly assaulted by a 30-year-old youth from her locality.The family members of the victim alleged that the accused, identified as Sahidul Seikh, tried to kill the girl after torturing her. The victim had several injurymarks on her body.They also alleged that the accused lured the victim with false promises and took her to an abandoned place on Monday afternoon. The minor girl did not hesitate to accompany him as he was an acquaintance. Also Read – Rain batters Kolkata, cripples normal lifeThe accused assaulted the victim, who fell ill after the incident. She was threatened with dire consequences if she revealed anything about the incident.The accused beat up the girl when she threatened to reveal about the incident to her parents. As the victim fell unconscious, the accused youth dumped her there and returned home.After a brief moment, the girl gained consciousness and locals heard her screams. They rushed the victim to Basanti block health centre and later, to Canning Sub-divisional hospital as her condition deteriorated. Meanwhile, her family members reached hospital. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedThey later lodged a complaint at the local police station on the basis of which police have started a probe. Medical tests also confirmed that the girl was tortured.Police are yet to record her statement. Her health condition is stated to be serious. The family members demanded stern action against the accused youth. Police have started a probe into the incident following the complaint. Raids are being conducted at various places of the district to nabthe culprit.last_img read more

Jazz up your winter wardrobe

first_imgWinter leaves fashionistas with restricted options of experimenting with colours, designs and cuts but one can try out some smart ways like layering and opting for classic pieces to make winter wear stylish.As the Seventies make a comeback at the International Fashion front this season (Chloe, Marc Jacobs, Alexander Wang), the leather dress with its sculptural shape and a rock-chic look, has become a must have in our Fall/Winter 2016-2017 wardrobe. Also Read – Add new books to your shelf Layering of garments is the most creative and yet the safest way to look classy and stylish during winters. All you need is a strong sense of personal style and a tad bit of creative genes within you, and you can have a lot of fun mixing and matching pieces from your wardrobe, even those which have been rendered so very last season! While planning the winter wardrobe one cannot ignore the trends of the season and what’s trending this season are the patches, badges and embroideries. Also Read – Over 2 hours screen time daily will make your kids impulsive For those who are not so experimental and more adhering to the classic looks, we recommend few classic pieces to them, to form looks which are tried and tested as well as instantly chic. Styles such as a knee length wool coat – one of the most classic winter fashions, a knit cardigan – ideal for layering under heavy wool coats in the winter. When it comes to winter fashion, neck accessories play a very essential role. They can add that extra zing to the ordinary winter ensembles for the day. With sportswear trending in the business of fashion, bomber jackets are no more associated with so much of masculinity and mundane look. In fact it has transcended in daring and feminine range of colours and designs for those who care to explore beyond the classic black look. When all is settled, we can come down to basics – the bottom wear. Choose from the stylish lycrated leggings with zipper details, enzyme washed and beautifully crafted denims and formal trousers. When worn over leg warmers you can still enjoy our embellished and embroidered denim shorts and keep those biker boots handy to complete the look.last_img read more

Sponsor Advertisement

first_imgSponsor Advertisement We’re still sitting here with nothing resolved…especially with the hideous and grotesque short positions in both gold and silver still in place.It was pretty quiet during Far East trading on their Monday. The high of the day was in shortly after 2:00 p.m. Hong Kong time…about fifty minutes before the London open…and it was all down hill until fifteen minutes after the Comex open in New York.The subsequent rally got capped…and then got sold off once the London p.m. gold fix was in at 3:00 p.m. BST…10:00 a.m. in New York..Gold closed at $1,709.80 spot…down $1.30 from Friday…and volume was anemic at 60,000 contracts, as most traders stayed home in advance of mega-hurricane Sandy.The silver chart looked identical to the gold chart.  Silver’s high tick came minutes after 10:00 a.m. Hong Kong time…but after that, silver’s price path was a carbon copy of gold’s.Silver finished the Monday trading session at $31.76 spot…down 33 cents on the day.  Volume was also very light…around 17,500 contracts.The other two precious metals got sold off as well.  It’s worth noting that even though the equity markets were closed…the precious metal and currency markets remained open.The dollar index closed at 79.997 on Friday…and worked its was slowly higher in fits and starts on Monday…closing at 80.23.  The high tick…30.31…came during the New York lunch hour.With the New York markets closed, there was no HUI…but the TSX Gold index here in Canada closed up just under a percent.Of course there was no Silver Sentiment Index either…but just eye-balling the silver stocks that I follow here in Canada on the Toronto Stock Exchange, I’m guessing that the silver stocks were down about a percent on average.The CME’s Daily Delivery Report showed that 8 gold and 24 silver contracts were posted for delivery within the Comex-approved warehouse system on Wednesday.  In silver, it was all the “usual suspects”…and that should just about be it for the October delivery month.  Tomorrow evening the CME should post the numbers for the November delivery month…and I’ll have that data for you on Wednesday.  The link to yesterday’s Issuers and Stoppers Report is here.Not surprisingly, there were no reported changes in either GLD or SLV…and the U.S. Mint had no sales report, either.The updated short positions for GLD and SLV were posted on the shortsqueeze.com Internet site late last week.  In silver, it showed that the short position jumped by 25.45%…from 11.65 million shares/ounces, all the way out to 14.62 million shares/ounces…454.7 tonnes.  It’s a good bet that an authorized participant shorted the shares rather than deposit real metal…which they didn’t have. They could have found it somewhere, I’m sure…but how high would they have had to bid the silver price to get it all?The short position in GLD actually declined by 6.54%…from 18.18 million shares, down to 16.99 million shares…or 1.70 million ounces…52.9 tonnes.The Comex-approved depositories reported receiving 596,425 troy ounces of silver on Friday…and didn’t ship any out.  The link to that activity is here.Being Tuesday, I have more than the usual compliment of stories…and I hope you can find the time to go through them all.  As usual, the final edit is up to you.Nor is the pressure to hold PHYSICAL Gold confined to the central banks. A trader in the city of London has an explanation of why Gold holdings in Exchange Traded Funds (ETFs) have not kept up their previous momentum in the period since 2004-2009. He says that “some investors” have moved from being comfortable with paper claims to Gold to a position where they are not confident unless they hold the physical metal itself. Nothing could be more probable. – Bill Buckler…Gold This Week…27 October 2012Well, I wouldn’t read a whole heck of a lot into yesterday’s trading action in all four precious metals.  But it was interesting to note that they followed their usual price paths…and they were all down on the day as well…plus the fact that they were trading at all, when the rest of the markets in New York were closed.  I guess JPMorgan et al never sleep when it comes to the price management scheme.Of course we’re still sitting here with nothing resolved…especially with the hideous and grotesque short positions in both gold and silver still in place.Today, at the close of Comex trading, is the cut-off for this Friday’s Commitment of Traders Report…and unless there are some big changes in price tomorrow I’m not expecting big changes in the COT Report either…as it has been a reasonably quiet week from a price point of view.By the way, I didn’t hear from anyone at Scotiabank or Scotia Mocatta yesterday, so they’ll be getting another request for an answer when I get out of bed later this morning.Not much happened in Far East trading on their Tuesday…but now that London has been open for a couple of hours, both metals are trading up from Monday’s close…a lot of which would have to do with the dollar index slide back to the 80.00 level.  Volumes, which had been pretty light at the London open, are now a bit more chunky, but nothing out of the ordinary…and it does appear from the price action that these rallies [as tiny as they are] are being met by the usual not-for-profit sellers.Before heading off to bed, I thought that some of you might be interested in this special sale [50% off the regular retail price] that Casey Research is having on the Casey Extraordinary Technology monthly report.Casey analyst Alex Daley has made a career of finding and monetizing big ideas….In fact, this was his main job when he worked for an elite team of technologists that reported to the CEO of one of America’s largest corporations. His group released some of the first smartphone apps, social networking sites and even did projects for large oil companies.But today Alex says he’s putting his money into a radical new technology that will soon make its way into millions of homes and offices across America and is expected to generate $3.7 billion in sales by 2015.Casey Research has recently made a video detailing his latest insights, including how you can take a position in this technological breakthrough right now. If you’re at all interested, click here to learn more.  This offer is only open until the end of tomorrow…Hallowe’en…and there are no tricks involved.  As a matter of fact, it’s my belief that Casey Research‘s standard 90-day guarantee of satisfaction applies.  How can you lose?That’s more than enough for one day…and it’s actually too much for one day, so I hope you were able to edit it to your satisfaction.See you tomorrow. Former Microsoft Inventor Reveals Big Tech WinnersFrom smartphone apps… to self-driving cars… to facial recognition software… Alex Daley and his team at Microsoft helped bring to market some of the most popular technologies of the past decade.In the process, Alex developed an uncanny knack for picking winning disruptive technologies, helping venture capitalists realize extraordinary gains. Now he’s identified a radical new technology that he expects to generate $3.7 billion in sales by 2015.All the details are in his new video – click here to see it now (it may not be up long, so please view it today).last_img read more

Several states are questioning the cost of using p

first_imgSeveral states are questioning the cost of using pharmacy middlemen to manage their prescription drug programs in a movement that could shake up the complex system that manages how pharmaceuticals are priced and paid for.The debate is playing out this week in an Ohio courtroom, as the state fights to release a report detailing what it paid two middlemen, CVS Health and Optum, to manage its Medicaid program’s prescription drug plans.The report shows that the companies charged the state 8.8 percent more than they paid to pharmacies to fill prescriptions. The companies kept the more than $224 million difference between what they charged the state and paid for the drugs.”I would love to tell you that 8.8 percent is too high, too low, or normal, but I’m really unqualified to say that because our state Medicaid program is the first state in the country to really get this level of transparency into how this works,” says Antonio Ciaccia, the director of government affairs for the Ohio Pharmacists Association.But he added, “I think 8.8 percent is insane.”Ohio’s Medicaid program is run almost completely through private managed care insurance companies. Those companies in turn contract with CVS Health and Optum to manage the prescription drug portion of recipients’ coverage. The companies — known as pharmacy benefit managers, or PBMs — negotiate discounts from drugmakers and work hard to keep the prices they actually pay secret.Ciaccia says that independent pharmacists became alarmed because their reimbursements from the two companies plummeted in recent years. He and a partner started a company, 46 Brooklyn, specifically to analyze drug prices and found that pharmacists were being paid sometimes only a fraction of what the middlemen were charging states.For example, Ohio paid the PBM $273.50 per unit for the generic version of Gleevec, a drug that treats leukemia and other cancers, while pharmacies reported the wholesale price of the drug was $83.69. In other words, the PBM charged the state more than the three times the price of the drug.Ohio’s Department of Medicaid commissioned its own analysis of its prescription drug program costs after the Columbus Dispatch newspaper reported the program was spending far more for prescription drugs than the pharmacies that filled those prescriptions were receiving.Last month the state released a summary that revealed the two companies were keeping 8.8 percent of the pharmacy budget. But when the state said it planned to release the entire report, CVS sued to stop it. Optum joined the suit this week and at a hearing Tuesday a judge told the companies to identify any trade secrets they want redacted by next month.Ohio Medicaid spokesman Tom Betti said in a statement that the state is committed to releasing the findings.”Transparency is not only the duty of government to its owners—the people of Ohio—but it’s also essential for the market to function properly. We believe this deeply and will continue to pursue it,” the statement said.If the analysis is released, it will offer an unprecedented look into the opaque world of pharmacy benefit managers and the mechanics of drug pricing.The findings in the analysis have angered state officials and Attorney General Mike DeWine has threatened to sue.”It is clear that the conduct by PBMs in these areas remains a major concern, and we anticipate that our investigation will result in major litigation against PBMs,” he said in a statement.CVS Health spokeswoman Christine Cramer pointed out that Ohio’s report concluded that the company saved the state about $145 million compared to an alternative system where the state pays a fee for each prescription filled.And she said releasing the report would hurt the company’s ability to negotiate low prices.”When it comes to the proprietary rates and formulas we use to negotiate for lower drug prices or cost-effective dispensing within our pharmacy network, making those figures public only hurts our ability to negotiate the lowest rates and fees in a highly competitive market, which would ultimately cost the state and the taxpayers more,” she said in a written statement.Optum did not respond to calls and emails for comment.”I think that Ohio is going to have an uphill battle when it comes to releasing this information,” says Stacie Dusetzina, a professor of health policy at Vanderbilt University School of Medicine. “It’s going to be fought very hard by CVS because they think it would set a standard for transparency and providing the public with this information.” She adds that efforts in other states to reveal drug pricing secrets have failed.Ohio isn’t alone in questioning the value of using middlemen to manage their prescription drug plans.States spend more than $33 billion a year on prescription drugs through their Medicaid programs and for many, that’s the fastest growing part of the Medicaid budget. So efforts to control those costs are front and center in many state budget debates.West Virginia last year stopped using pharmacy benefit managers altogether. And Kentucky is also doing an analysis of its costs while lawmakers consider legislation that would require pharmacy benefit managers that contract with Medicaid to report details of their costs to the state and ensure they pay independent pharmacies a fair price.And In Iowa, State Representative John Forbes — who’s also a pharmacist — launched his own investigation into a county government health plan a few months ago after hearing complaints from pharmacists.”We went through the records for this county over about a three-month period and found that, in many cases, the pharmacies were being paid $5 to $10 for prescriptions, but the county entity was being billed over $100 for those same prescription medications,” Forbes said in an interview.He says the oversight committee in Iowa’s legislature now plans to investigate the PBM’s practices. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Regulators Keep Punishing Square for Doing Nothing Wrong

first_img Regulators Keep Punishing Square for Doing Nothing Wrong Technology 2019 Entrepreneur 360 List –shares Do U.S. citizens really need to be protected from Square?The mobile-payment processor has lost another regulatory fight, this time in Florida, where it agreed to pay a $507,000 fine to settle charges it operated in that state without a money-transmission license.Square has been the subject of such spats before, in its home state of California and Illinois, where it actually faced a high-profile cease-and-desist order before getting a license.There remains a valid legal question to these licensure fights: Since Square simply processes payment information, and doesn’t actually transmit money itself, why should it have to fall under the transmission regulations of all 50 states?Related: U.S. Regulators Aim to Close ‘Wild West’ Frontier of BitcoinPresumably, Square has made a decision that, rather than fight each jurisdiction, it will just bend a knee before the regulators, pay whatever fees it needs to in order to fall under their framework, and happily go about its business. Indeed, it has big plans, and there is a good business reason for the company to not stand its ground and fight back.Still, the controversy over Square regulation remains troubling for those outside the company, particularly those entrepreneurs with financial businesses who want to operate across the nation.For one thing, Square’s acquiescence leaves the legal issues unresolved. Square was not a money transmitter by any definition. True, its business changed somewhat when it unveiled plans to get into the gift-card business, but the Florida action doesn’t address that move. The fine Square is paying covers a period of time from February 2010 to November 2012 when it was simply processing transactions.Square could have avoided the fine by fighting its case. That could have led to a precedent that it could use in navigating the Byzantine regulatory frameworks financial-services companies face wherever they do business. Instead, it coughed up $507,000 – small beer to a company that has raised well north of $300 million – and left the fight to others. (To be fair, Square isn’t alone. In its infancy, PayPal decided such a battle wasn’t worth its trouble either.)In addition to not settling the law, Square’s surrender doesn’t allow us to address a key point of the regulations themselves: What ill befell the citizens of Florida from 2010 to 2012 because Square operated without a license? Proponents of regulations like to point out that government’s role is to protect citizens from harm, particularly from greedy businessmen who pick pockets and poison kittens on their way to the top. Government’s noble role is necessary to keep free enterprise from giving in to its baser nature when the sun goes down.Related: Why the EPA and FAA Are Killing Elon Musk’s Better IdeaBut no one can say that Square did anything wrong – or was even in a position to – in Florida or any other state. It processed transactions for merchants and took a cut off the top. It didn’t hold a single dollar, ruble, Deutsche mark or Bitcoin along the way. Merchants could have screwed their customers, and banks could have screwed their merchants, but Square was chaste.Still, asking if someone is actually harmed is no longer a litmus test for the promulgation of regulations. In this case, existing laws never anticipated a company like Square in the first place – a testament to Jack Dorsey’s innovation. Faced with something they had never seen before, regulators decided to pound this Square peg into Florida’s round holes and declare victory.It could have been worse – and may still be. One could argue this is the best-case scenario, since lawmakers always have the option of creating new laws which lead to the promulgation of new regulations that are often worse than the ones before. Rarely is there true reform when it comes to laws and regulations. Rather, there is addition. Only in the legislative world does one ease a burden by adding more weight.Square, for its part, no doubt made the right move for business reasons. But one can’t help but despair of the missed opportunity to make regulators stop bullying entrepreneurs whose innovations are light-years ahead of our regulatory framework. Until some company or business owner draws a line in that sand, businesses will be at more risk of harm than the consumers our lawmakers and bureaucrats seem so eager to protect.Related: Why California Can’t Be Home to the Hyperloop Editor-at-Large Ray Hennessey August 16, 2013 Opinions expressed by Entrepreneur contributors are their own.center_img Image credit: Digital Trends Add to Queue Guest Writer The only list that measures privately-held company performance across multiple dimensions—not just revenue. Next Article 4 min read Apply Now »last_img read more

Think China is the No 1 Country for Hacking Think Again

first_img China has earned a reputation as the hacker capital of the world, but a new report shows the bulk of global cyber-attack activity has recently come from its smaller neighbor Indonesia.Thirty-eight percent of cyber attacks originated in Indonesia during the second quarter of 2013, up from 21 percent in the first quarter, according to a report by security cloud platform Akamai. This spike helped push China off the hacking pedestal, with the world’s most populous country accounting for 33 percent of attacks, down from 34 percent in the previous quarter. The U.S. rounded out the top three, generating 6.9 percent of cyber-attack traffic, a decrease from 8.3 percent.Indonesia and China alone accounted for more than half of all cyber-attack activity during the quarter.Related: Don’t Get Hacked — Tools to Fight Cyber AttacksWhile it may seem like Indonesia came out of nowhere to take the lead (last year the country accounted for on average less than one percent of cyber crimes), hackers may be taking advantage of its increase in connection and weakening IT structure. The country’s average internet connection speed increased 125 percent in the second quarter from the same time last year. That, coupled with the fact the country isn’t spending a whole lot of cash on its infrastructure,  may make the country a haven for cybercriminals.Related: Cyber Security a Growing Issue for Small Business In January, hacker group Anonymous Indonesia claimed responsibility for defacing 12 government websites with the tagline “No Army Can Stop an Idea” shown on the sites. In April, the country’s defense minister Purnomo Yusgiantoro announced they were building a Cyber Defense Center to take on hackers. Microsoft also felt the supposed wrath of Indonesia criminals (among others) when it put the kibosh on a cybercrime operation in June. Akamai’s findings are based on agents reporting log connection attempts, which the company defines as attack traffic. The company then can determine the top countries the hack attacks occur. One caveat to keep in mind: the IP address assigned to a particular country may not be the nation the attacker resides. So someone from China with an IP address associated with them, may be committing cyber attacks in France.To check out more of Akamai’s findings, check out the below highlights:Click to Enlarge+ October 16, 2013 Special Projects Director and Founder of This Dog’s Life Think China is the No. 1 Country for Hacking? Think Again. Next Article Andrea Huspeni Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now »center_img Technology Entrepreneur Staff 2 min read Free Webinar | July 31: Secrets to Running a Successful Family Business –shares Add to Queuelast_img read more

HP Enterprise Strikes 88 Billion Deal With Micro Focus for Software Assets

first_imgHewlett-Packard Hewlett-Packard Enterprise agreed to sell its software business to Micro Focus in a $8.8 billion deal that shrinks the Silicon Valley pioneer again while catapulting the little-known British firm into the top tier of European tech companies.Autonomy, the British firm bought by HP in an ill-fated $11 billion push into software just five years ago, will return to British control after the deal for far below its original price.HPE Chief Executive Meg Whitman is focusing the group on a few areas such as networking, storage and technology services since it separated last year from computer and printer maker HP Inc.”Micro Focus’s approach to managing both growing and mature software assets will ensure higher levels of investment in growth areas, like big data analytics and security, while maintaining a stable platform for … software products that customers rely on,” she said.Micro Focus approached HPE in February, four months before Britain voted to leave the European Union in a shock referendum that initially spooked global financial markets, the British firm’s executive chairman, Kevin Loosemore, said.It is the second big deal involving a British company since the June 23 Brexit vote that many feared would put the brakes on mergers. It is also a relatively rare example of a British company buying U.S. technology assets.Loosemore spotted another opportunity to profit from managing old software. Companies including banks and airlines pay Micro Focus to extend the life of the computers they use to run their businesses, for example to manage data. This allows the companies to avoid spending on newer computer systems.”(It) is entirely consistent with our established acquisition strategy and our focus on efficient management of mature infrastructure products,” he told reporters on a conference call from New York.Boring but profitableShares in Micro Focus, based in Newbury, southern England, jumped by a fifth to an all-time high of 2,400 pence, topping the FTSE 100 index of leading shares that it joined days ago, after chip designer ARM Holdings was bought by Japan’s Softbank Corp.Micro Focus, with a market capitalization of 4.45 billion pounds ($6 billion) before the deal, has been snapping up software companies. This would be its largest deal to date. Earlier this year, it acquired U.S. firm Serena Software for $540 million.Loosemore said he would bring the core earnings margin for the mature assets in the deal — about 80 percent of the total — from 21 percent today to Micro Focus’s existing 46 percent level within three years.”The way we do it is really just lots of 101, boring management,” he said. “Too often people chase unattainable growth rates and in doing so they waste a lot of money.”A serial acquirer of software platforms, Micro Focus has also shifted strategy to buying higher growth software such as SUSE, the world’s No.2 maker of Linux software while wringing the most out of aging software.”This strategy works well for current shareholders, who gain significant ownership in better-run businesses,” said UBS analyst Steve Milunovich, who tracks HP Enterprise.The deal, announced along with HPE’s latest quarterly earnings, came on the same day that Dell and EMC Corp completed their merger in a deal that unites two of HPE’s biggest rivals.In the third quarter, HPE reported net revenue of $12.2 billion, down 6 percent from $13.1 billion a year earlier. The transaction is expected to be tax free to HP.The deal is the latest in a series of asset disposals by HPE, which agreed in May to spin off and merge its struggling technology services business to Computer Sciences Corp., in a transaction valued around $8.5 billion.The sale will mean two-thirds of HPE’s remaining business will be hardware, which is fast becoming a commodity, UBS’s Milunovich said. It could make the company a more agile competitor but also could make it harder to compete with far larger companies such as Cisco and Dell.Micro Focus will pay $2.5 billion in cash to HPE, while HPE shareholders will own 50.1 percent of the combined company that will operate under the name Micro Focus and be run by its executives. HPE said it would pay $700 million in one-time costs related to the separation of the assets.Autonomy back in BritainIn the deal, HPE is sending one of the British firms it acquired back to where it started.HPE acquired part of its software portfolio through HP’s $11 billion purchase of Autonomy in 2011, a deal that was supposed to form the central part of the U.S. group’s move into software. HP later wrote off three-quarters of the company’s value.”Some of those [Autonomy] products are very exciting, some of them are more mature,” Loosemore said.Other HPE assets that will be merged include software for application delivery management, big data, enterprise security, information management & governance and IT Operations management businesses.By acquiring the HP Enterprise software assets, the deal thrusts Micro Focus into the top ranks of European software makers. It would rank around sixth in market capitalization terms among regional software names.Since sterling tumbled on the Brexit result, many British companies have become more attractive for international suitors.Loosemore said, however, the Brexit vote didn’t change the dynamic. “If you map our share price in dollars rather than pounds it’s pretty consistent,” he said. “So no real effect.”(By Paul Sandle and Liana B. Baker; Additional reporting by Eric Auchard; Editing by Kate Holton, Guy Faulconbridge, Anna Willard) Free Webinar | July 31: Secrets to Running a Successful Family Business Add to Queue –shares Image credit: Eugene Berman | Shutterstock.com 5 min read Reuters HP Enterprise Strikes $8.8 Billion Deal With Micro Focus for Software Assets September 8, 2016 Chief Executive Meg Whitman is focusing the group on a few areas such as networking, storage and technology services since it separated last year from computer and printer maker HP Inc. This story originally appeared on Reuters Next Article Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now »last_img read more

Salesforce Joins New Continuous Delivery Foundation As Premier Member

first_imgSalesforce Joins New Continuous Delivery Foundation As Premier Member PRNewswireJuly 1, 2019, 6:24 pmJuly 1, 2019 CD/CI ToolsContinuous Delivery FoundationcrmMarketing TechnologyNewsPremier MemberSalesforce Previous ArticleNew Auto Dealership Study Reveals Active Listening Over the Phone Directly Increases Customer Visits and SalesNext ArticleSharpend Poaches Anthem’s Hollands to Boost Senior Team With First MD Global CRM Leader Joins Community Committed to Growing Ecosystem of CD/CI Tools and MethodologiesThe Continuous Delivery Foundation (CDF), the vendor-neutral home for many of the fastest-growing projects for continuous delivery, announced that Salesforce has joined the CDF as a premier member.Salesforce joins other CDF premier members such as Cloudbees, IBM, Google, CapitalOne, CircleCI, jFrog, Huawei, and Netflix working together to make continuous delivery tools and processes as accessible and reliable as possible and grow the overall ecosystem.Salesforce is increasingly adopting continuous delivery practices and tools to empower development teams to achieve a faster, more frequent release cycle. As a CDF member, Salesforce will help shape industry specifications around pipelines, workflows and other CI/CD areas, as well as provide foundational support for CI/CD tools.“An ethos of community innovation is driving the next generation of enterprise software,” said Mark Interrante, SVP of Engineering, Salesforce. “Salesforce is proud to join the Continuous Delivery Foundation and empower developers everywhere to deliver apps at enterprise levels of trust, scale and performance.”Marketing Technology News: Constant Contact Unveils New WooCommerce and Shopify Offerings at 2019 Internet Retailer Conference“With over 20 years of experience building software at scale, Salesforce has a lot of expertise to share with the community,” said Chris Kelly, Director of Open Source, Salesforce. “By collaborating with the CDF, we’re excited to help define the future of open source CI/CD tools, share our lessons learned as well as build on the industry’s experience.”Open source technologies such as Jenkins, JenkinsX, Spinnaker and Tekton, which are hosted by the CDF, help development teams from companies of all sizes and industries improve their speed and productivity when creating cloud-native, legacy infrastructure, mobile, IoT, and bare metal applications.“Salesforce is an established, global CRM leader, and we’re thrilled they’re working with us to help enterprises adopt CD delivery as quickly and easily as possible,” said Dan Lopez, CDF program manager. “With containers, microservices and Kubernetes on the rise, Salesforce and other CDF members have a key role to play in growing and sustaining the CI/CD ecosystem. With CDF members focused on this, software development teams are free to focus on delivering quick, stable code changes as easily as possible.”Marketing Technology News: Broadvoice Welcomes Kim McLachlan as Senior Vice President of Sales and MarketingSalesforce and other CDF members have hosting Continuous Delivery Summits this year, including events co-located with KubeCon + CloudNativeCon + Open Source Summit China and KubeCon + CloudNativeCon North America respectively. Details for the Continuous Delivery Summit in San Diego will be coming soon.Salesforce is also a member of the Linux Foundation, the Cloud Native Computing Foundation, Hyperledger, the Internet Security Research Group/Let’s Encrypt, and the OpenAPI initiative.Marketing Technology News: CoSchedule Launches Marketing Suite to Transform the Way Marketers Worklast_img read more

Structured Social Named Facebook Preferred Agency Partner

first_img FacebookMarketing Technology NewsNewsNick ShackelfordStructured Social Previous ArticleNimble Now Selling Its Simple CRM for Office 365 Globally Through Microsoft’s New Commercial MarketplaceNext ArticleRetail App Use Surges 50% As Consumers Shop Year-Round, Taking Pressure Off the “Make or Break’ Holiday Season Structured Social is proud to announce it has been named one of the first recipients of the Preferred Agency Partners Badge under social media giant Facebook’s newly revamped partner program.The Facebook Preferred Marketing Developer program, or PMD, was created to help a business scale its marketing efforts on the Facebook platform. It involves a community of more than 45 countries designed to help marketers and advertisers establish and grow lasting connections with customers. The partnership affords Structured Social access to one-on-one support, advanced tools, training and support, and exclusive opportunities.Marketing Technology News: Introducing Shutterstock Elements, Thousands of Cinema-Grade Video Effects for Filmmakers“Clients know the e-commerce world is more competitive than it has ever been, and they are looking to work with companies that have a real edge,” said Structured Social Co-Founder Nick Shackelford. “This new partnership gives us the type of advantage that will allow us to develop new opportunities for our partners and increase revenue in a substantial way.”Marketing Technology News: GCOM Software Announces Ernie Connon as New Chief Growth OfficerStructured Social has been one of the leading e-commerce companies helping consumer-focused companies drive revenue growth by providing expert consulting on offer structure, page design, paid social campaigns and partnerships with brands. The recognition from Facebook serves as recognition for the company’s efforts, proof that Structured Social is on the right path and clearly demonstrates the company’s position in the marketplace.Marketing Technology News: Blackstone Announces Agreement to Acquire Vungle, a Leading Mobile Performance Marketing Platform Structured Social Named Facebook Preferred Agency Partner MTS Staff Writer6 days agoJuly 17, 2019 last_img read more

Study analyzes vaccinepreventable infections in children who receive solid organ transplants

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 15 2019Children who receive solid organ transplants are hospitalized due to vaccine-preventable infections at rates that are significantly higher than the general population, according to a newly published study by University of Colorado School of Medicine researchers.The study, published today in JAMA Pediatrics, reviewed nearly 7,000 transplant recipients nationally over a seven-year period beginning Jan. 1, 2004, to determine how often they are hospitalized with infections that are typically prevented with vaccines.Of the 6,980 transplant recipients in the study, 1,092 patients, or 15.6 percent, were hospitalized with a total of 1,490 cases of vaccine-preventable infections within five years after transplant surgery. At that rate, hospitalization among the transplant population was up to 87 times higher than in the general population.Related StoriesMore effective flu vaccine begins clinical trials across the U.S.Researchers develop improved vaccine for meningitis and bloodstream infectionsVaccine drama on display in California’s Capitol”The huge burden of illness from vaccine-preventable infections that we show in this article should stress to all physicians the critical importance of ensuring that all transplant patients receive age-appropriate immunizations,” said the study’s lead author, Amy Feldman, MD, MSCS, assistant professor of pediatrics for the CU School of Medicine and program director for the liver transplant fellowship at Children’s Hospital Colorado on the Anschutz Medical Campus.While other studies have looked at morbidity from certain types of infections, this study is the first to explore the burden of illness from all vaccine-preventable infections across the entire pediatric solid organ transplant population. The analysis included all patients younger than 18 years old who underwent a heart, lung, liver, kidney, intestine, or multivisceral transplant at any of the 45 U.S. not-for-profit tertiary care pediatric hospitals that report data to the Pediatric Health Information System of the Children’s Hospital Association.Based on the findings, Feldman and her co-authors recommend further study to identify ways to improve the likelihood of vaccination among children who need transplant surgery. The goal is to reduce the costs of hospitalization and the rates of sickness and death due to infections that could be prevented by vaccination. Source:http://www.ucdenver.edu/last_img read more

Study shows benefits of including red raspberries in the diet of people

first_img Source:https://web.iit.edu/ Reviewed by James Ives, M.Psych. (Editor)Feb 26 2019A study released today from the Illinois Institute of Technology shows the benefits of including red raspberries in the diet of individuals with pre-diabetes and insulin resistance.According to the Centers for Disease Control and Prevention (CDC), an estimated 34 percent of American adults, around 84.1 million in all, had prediabetes in 2015. Patients with prediabetes are at higher risk for a number of conditions – including developing type 2 diabetes, cardiovascular disease and Alzheimer’s disease.The study, published in Obesity, investigated the effects of red raspberries in a group of people at-risk for diabetes who were overweight or obese and presented with prediabetes and insulin resistance. A metabolically healthy control group was also included in the study for reference.Related StoriesIntermittent fasting may protect against type 2 diabetesDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesNew biomaterial could encapsulate and protect implanted insulin-producing cellsUsing a randomized, controlled, acute study design, 32 adults between the ages of 20-60 years had their blood tested over a 24-hour period after eating breakfast on three separate days. The three breakfast meals were similar in calories and macronutrients, but differed in the amount of frozen red raspberries – one meal contained no raspberries, one contained one cup of raspberries and one contained two cups of raspberries.The results showed that as the amount of raspberry intake increased, individuals at risk for diabetes needed less insulin to manage their blood glucose. When two cups of red raspberries were included in the meal, glucose concentrations were lower compared to the meal with no red raspberries. The data suggests that simple inclusion of certain fruits, such as red raspberries with meals, can have glucose lowering benefits with indications of improvements in insulin responses. These effects are particularly important for people who are overweight or obese with pre-diabetes.”People at risk for diabetes are often told to not eat fruit because of their sugar content. However, certain fruits – such as red raspberries – not only provide essential micronutrients, but also components such as anthocyanins, which give them their red color, ellagitannins and fibers that have anti-diabetic actions,” said Britt Burton-Freeman, Ph.D., director, Center for Nutrition Research at Illinois Tech. “For people who are at risk for diabetes, cardiovascular disease and other health risks, knowing what foods have protective benefits and working them into your diet now can be an important strategy for slowing or reversing progression to disease.”last_img read more

Researchers unravel the biology of how obesity promotes triplenegative breast cancer

first_img Source:https://www.uchicagomedicine.org/ Reviewed by Alina Shrourou, B.Sc. (Editor)May 7 2019Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has been gaining ground. A new study from researchers at the University of Chicago finds that women with breast cancer, the most common cancer among women, are at even higher risk from obesity.Breast cancers occur in adipose tissue, better known as fat. Triple-negative breast cancer (TNBC) is a type of breast cancer that is particularly difficult to treat. None of the three most appealing drug targets — the estrogen receptor, the progesterone receptor and human epidermal growth factor receptor 2 — are present on TNBC cells.”These cancers can be particularly aggressive,” said study author Lev Becker, PhD, an assistant professor in the Ben May Department for Cancer Research at the University of Chicago. “For patients with TNBC, there are few therapeutic options. The survival rate is quite low. And the cancer tends to be dramatically elevated in patients who are overweight or obese.”Obesity has become “a global epidemic,” Becker said. The prevalence in the United States is about 36 percent for ages 20 to 39, 43 percent for ages 40 to 59, and 41 percent for those 60 and older. The United States is ranked 12th worldwide for obesity.”Current treatment of breast cancer patients ignores the ongoing obesity epidemic,” said study co-author Marsha Rosner, PhD, the Charles B. Huggins Professor in the Ben May Department for Cancer Research. “In order to take this into consideration, we need to help patients lose weight or identify new drug targets that would be effective in obese cancer patients.”Unfortunately, once the cancer has been detected there may not be time to lose weight prior to treatment. “So our bottom line,” Rosner said, is to “promote weight loss as a cancer prevention measure, incorporate weight loss as a component of therapy for patients with breast cancer, and develop specific drug targets that could be leveraged to address the obesity component of the disease.”Related StoriesStudy reports role of cancer gene in tumor microenvironmentHarnessing target of the brain chemical serotonin to combat obesityBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryIn their paper, “Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer,” published May 3, 2019 in the Journal of Experimental Medicine, Becker, Rosner and colleagues unravel the biology of how obesity promotes TNBC. They show that obesity reprograms macrophages — scavenger white blood cells that can devour invaders such as bacteria, viruses or tumor cells — into pro-inflammatory, metabolically-activated macrophages. Instead of fighting breast cancer, these immune cells actually promote it.”Our studies, in mice and humans,” Becker added, “implicate these metabolically-activated adipose tissue macrophages.” They accumulate in mammary adipose tissue. They release interleukin 6, a pro-inflammatory cytokine which can fuel tumorigenesis. And they thrive on obesity.Interleukin 6 binds to a receptor on the surface of existing cancer cells. That can create “an even more aggressive stem cell phenotype,” Becker said. “These cancer stem cells are able to encourage tumor growth and metastasis, enabling them to travel to other sites.” Patients with advanced or metastatic cancer have higher levels of IL-6 in their blood, which is correlated with poor survival rates.Obesity, the study authors wrote, is a pathological state that “facilitates tumorigenesis by creating tumor permissive conditions in multiple tissues.” This suggests that chronic inflammation and its effects on tumorigenesis may be reversed by targeted anti-inflammatory therapies or by weight loss. Indeed, the researchers found that inducing weight loss in obese mice by feeding them a healthier low-fat diet reversed macrophage inflammation and TNBC tumor formation in mammary fat, even though their body weight remained elevated. These findings highlight the potential value of weight loss, not only as a preventive intervention but even after patients develop breast cancer.last_img read more